Cargando…

The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells

Recently, magnetic nanoparticles of iron oxide (Fe(3)O(4), γ-Fe(2)O(3)) have shown an increasing number of applications in the field of biomedicine, but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work, the three type...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Song, Chen, Xiangjian, Gu, Chunrong, Zhang, Yu, Xu, Jindan, Bian, Zhiping, Yang, Di, Gu, Ning
Formato: Texto
Lenguaje:English
Publicado: Springer 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894190/
http://dx.doi.org/10.1007/s11671-008-9204-7
_version_ 1782183154652545024
author Zhang, Song
Chen, Xiangjian
Gu, Chunrong
Zhang, Yu
Xu, Jindan
Bian, Zhiping
Yang, Di
Gu, Ning
author_facet Zhang, Song
Chen, Xiangjian
Gu, Chunrong
Zhang, Yu
Xu, Jindan
Bian, Zhiping
Yang, Di
Gu, Ning
author_sort Zhang, Song
collection PubMed
description Recently, magnetic nanoparticles of iron oxide (Fe(3)O(4), γ-Fe(2)O(3)) have shown an increasing number of applications in the field of biomedicine, but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work, the three types of magnetic nanoparticles (DMSA-Fe(2)O(3), APTS-Fe(2)O(3), and GLU-Fe(2)O(3)) with the same crystal structure, magnetic properties, and size distribution was designed, prepared, and characterized by transmission electronic microscopy, powder X-ray diffraction, zeta potential analyzer, vibrating sample magnetometer, and Fourier transform Infrared spectroscopy. Then, we have investigated the effect of the three types of magnetic nanoparticles (DMSA-Fe(2)O(3), APTS-Fe(2)O(3), and GLU-Fe(2)O(3)) on smooth muscle cells (SMCs). Cellular uptake of nanoparticles by SMC displays the dose, the incubation time and surface property dependent patterns. Through the thin section TEM images, we observe that DMSA-Fe(2)O(3)is incorporated into the lysosome of SMCs. The magnetic nanoparticles have no inflammation impact, but decrease the viability of SMCs. The other questions about metabolism and other impacts will be the next subject of further studies.
format Text
id pubmed-2894190
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Springer
record_format MEDLINE/PubMed
spelling pubmed-28941902010-06-30 The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells Zhang, Song Chen, Xiangjian Gu, Chunrong Zhang, Yu Xu, Jindan Bian, Zhiping Yang, Di Gu, Ning Nanoscale Res Lett Nano Express Recently, magnetic nanoparticles of iron oxide (Fe(3)O(4), γ-Fe(2)O(3)) have shown an increasing number of applications in the field of biomedicine, but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work, the three types of magnetic nanoparticles (DMSA-Fe(2)O(3), APTS-Fe(2)O(3), and GLU-Fe(2)O(3)) with the same crystal structure, magnetic properties, and size distribution was designed, prepared, and characterized by transmission electronic microscopy, powder X-ray diffraction, zeta potential analyzer, vibrating sample magnetometer, and Fourier transform Infrared spectroscopy. Then, we have investigated the effect of the three types of magnetic nanoparticles (DMSA-Fe(2)O(3), APTS-Fe(2)O(3), and GLU-Fe(2)O(3)) on smooth muscle cells (SMCs). Cellular uptake of nanoparticles by SMC displays the dose, the incubation time and surface property dependent patterns. Through the thin section TEM images, we observe that DMSA-Fe(2)O(3)is incorporated into the lysosome of SMCs. The magnetic nanoparticles have no inflammation impact, but decrease the viability of SMCs. The other questions about metabolism and other impacts will be the next subject of further studies. Springer 2008-12-02 /pmc/articles/PMC2894190/ http://dx.doi.org/10.1007/s11671-008-9204-7 Text en Copyright ©2008 to the authors
spellingShingle Nano Express
Zhang, Song
Chen, Xiangjian
Gu, Chunrong
Zhang, Yu
Xu, Jindan
Bian, Zhiping
Yang, Di
Gu, Ning
The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
title The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
title_full The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
title_fullStr The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
title_full_unstemmed The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
title_short The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
title_sort effect of iron oxide magnetic nanoparticles on smooth muscle cells
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894190/
http://dx.doi.org/10.1007/s11671-008-9204-7
work_keys_str_mv AT zhangsong theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT chenxiangjian theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT guchunrong theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT zhangyu theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT xujindan theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT bianzhiping theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT yangdi theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT guning theeffectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT zhangsong effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT chenxiangjian effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT guchunrong effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT zhangyu effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT xujindan effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT bianzhiping effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT yangdi effectofironoxidemagneticnanoparticlesonsmoothmusclecells
AT guning effectofironoxidemagneticnanoparticlesonsmoothmusclecells