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Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System

Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimen...

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Detalles Bibliográficos
Autores principales: Zhou, Huafeng, Yue, Yang, Liu, Guanlan, Li, Yan, Zhang, Jing, Gong, Qiu, Yan, Zemin, Duan, Mingxing
Formato: Texto
Lenguaje:English
Publicado: Springer 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894193/
https://www.ncbi.nlm.nih.gov/pubmed/20652152
http://dx.doi.org/10.1007/s11671-009-9469-5
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author Zhou, Huafeng
Yue, Yang
Liu, Guanlan
Li, Yan
Zhang, Jing
Gong, Qiu
Yan, Zemin
Duan, Mingxing
author_facet Zhou, Huafeng
Yue, Yang
Liu, Guanlan
Li, Yan
Zhang, Jing
Gong, Qiu
Yan, Zemin
Duan, Mingxing
author_sort Zhou, Huafeng
collection PubMed
description Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol resulted in a smaller size LNE droplet and increasing viscosity, respectively. The droplet size of optimized LNE, with the glycerol concentration above 75% (w/w), changed from 92 (F10) to 58 nm (F14). Additionally, LNE, incorporated into o/w cream, improved the skin hydration capacity of the cream significantly with about 2.5-fold increase when the concentration of LNE reached 10%. LNE was also demonstrated to improve the penetrability of Nile red (NR) dye into the dermis layer, when an o/w cream, incorporated with NR-loaded LNE, applied on the abdominal skin of rat in vivo. Specifically, the arbitrary unit (ABU) of fluorescence in the dermis layer that had received the cream with a NR-loaded LNE was about 9.9-fold higher than the cream with a NR-loaded general emulsion (GE). These observations suggest that LNE could be used as a promising topical delivery vehicle for lipophilic compounds.
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spelling pubmed-28941932010-07-21 Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System Zhou, Huafeng Yue, Yang Liu, Guanlan Li, Yan Zhang, Jing Gong, Qiu Yan, Zemin Duan, Mingxing Nanoscale Res Lett Nano Express Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol resulted in a smaller size LNE droplet and increasing viscosity, respectively. The droplet size of optimized LNE, with the glycerol concentration above 75% (w/w), changed from 92 (F10) to 58 nm (F14). Additionally, LNE, incorporated into o/w cream, improved the skin hydration capacity of the cream significantly with about 2.5-fold increase when the concentration of LNE reached 10%. LNE was also demonstrated to improve the penetrability of Nile red (NR) dye into the dermis layer, when an o/w cream, incorporated with NR-loaded LNE, applied on the abdominal skin of rat in vivo. Specifically, the arbitrary unit (ABU) of fluorescence in the dermis layer that had received the cream with a NR-loaded LNE was about 9.9-fold higher than the cream with a NR-loaded general emulsion (GE). These observations suggest that LNE could be used as a promising topical delivery vehicle for lipophilic compounds. Springer 2009-10-29 /pmc/articles/PMC2894193/ /pubmed/20652152 http://dx.doi.org/10.1007/s11671-009-9469-5 Text en Copyright ©2009 to the authors
spellingShingle Nano Express
Zhou, Huafeng
Yue, Yang
Liu, Guanlan
Li, Yan
Zhang, Jing
Gong, Qiu
Yan, Zemin
Duan, Mingxing
Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
title Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
title_full Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
title_fullStr Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
title_full_unstemmed Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
title_short Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
title_sort preparation and characterization of a lecithin nanoemulsion as a topical delivery system
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894193/
https://www.ncbi.nlm.nih.gov/pubmed/20652152
http://dx.doi.org/10.1007/s11671-009-9469-5
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