Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain...

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Detalles Bibliográficos
Autores principales: Purtov, KV, Petunin, AI, Burov, AE, Puzyr, AP, Bondar, VS
Formato: Texto
Lenguaje:English
Publicado: Springer 2010
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894223/
https://www.ncbi.nlm.nih.gov/pubmed/20672079
http://dx.doi.org/10.1007/s11671-010-9526-0
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author Purtov, KV
Petunin, AI
Burov, AE
Puzyr, AP
Bondar, VS
author_facet Purtov, KV
Petunin, AI
Burov, AE
Puzyr, AP
Bondar, VS
author_sort Purtov, KV
collection PubMed
description Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody–antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.
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spelling pubmed-28942232010-07-28 Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances Purtov, KV Petunin, AI Burov, AE Puzyr, AP Bondar, VS Nanoscale Res Lett Nano Express Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody–antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo. Springer 2010-01-19 /pmc/articles/PMC2894223/ /pubmed/20672079 http://dx.doi.org/10.1007/s11671-010-9526-0 Text en Copyright © 2010 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Nano Express
Purtov, KV
Petunin, AI
Burov, AE
Puzyr, AP
Bondar, VS
Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances
title Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances
title_full Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances
title_fullStr Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances
title_full_unstemmed Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances
title_short Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances
title_sort nanodiamonds as carriers for address delivery of biologically active substances
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894223/
https://www.ncbi.nlm.nih.gov/pubmed/20672079
http://dx.doi.org/10.1007/s11671-010-9526-0
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AT puzyrap nanodiamondsascarriersforaddressdeliveryofbiologicallyactivesubstances
AT bondarvs nanodiamondsascarriersforaddressdeliveryofbiologicallyactivesubstances

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