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Caudal Clonidine in Day-Care Paediatric Surgery

SUMMARY: We evaluated the analgesic efficacy, hemodynamic and respiratory safety of Clonidine when added to bupivacaine for caudal block. Forty children undergoing inguinal hernia repair were randomly given caudal injection with 0.75 ml.kg(−1) of bupivacaine (0.25%) and clonidine 2 μg.kg(−1) in Grou...

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Detalles Bibliográficos
Autores principales: Koul, Archna, Pant, Deepanjali, Sood, Jayshree
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894500/
https://www.ncbi.nlm.nih.gov/pubmed/20640207
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author Koul, Archna
Pant, Deepanjali
Sood, Jayshree
author_facet Koul, Archna
Pant, Deepanjali
Sood, Jayshree
author_sort Koul, Archna
collection PubMed
description SUMMARY: We evaluated the analgesic efficacy, hemodynamic and respiratory safety of Clonidine when added to bupivacaine for caudal block. Forty children undergoing inguinal hernia repair were randomly given caudal injection with 0.75 ml.kg(−1) of bupivacaine (0.25%) and clonidine 2 μg.kg(−1) in Group C or 0.75 ml.kg(−1) of bupivacaine (0.25%) alone in Group B after induction of anaesthesia. Postoperatively duration of analgesia, OPS score (observational pain / discomfort scale), Sedation score, heart rate and blood pressure were recorded. Duration of analgesia was significantly longer (p<0.001) in Group C (10.25 hours) as compared to 4.55 hours in Group B. Bradycardia, hypotension and sedation were not observed in Group C. The addition of Clonidine in caudal blocks prolongs postoperative pain relief in children and is safe alternative to bupivacaine alone in paediatric daycare surgeries.
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spelling pubmed-28945002010-07-16 Caudal Clonidine in Day-Care Paediatric Surgery Koul, Archna Pant, Deepanjali Sood, Jayshree Indian J Anaesth Clinical Investigation SUMMARY: We evaluated the analgesic efficacy, hemodynamic and respiratory safety of Clonidine when added to bupivacaine for caudal block. Forty children undergoing inguinal hernia repair were randomly given caudal injection with 0.75 ml.kg(−1) of bupivacaine (0.25%) and clonidine 2 μg.kg(−1) in Group C or 0.75 ml.kg(−1) of bupivacaine (0.25%) alone in Group B after induction of anaesthesia. Postoperatively duration of analgesia, OPS score (observational pain / discomfort scale), Sedation score, heart rate and blood pressure were recorded. Duration of analgesia was significantly longer (p<0.001) in Group C (10.25 hours) as compared to 4.55 hours in Group B. Bradycardia, hypotension and sedation were not observed in Group C. The addition of Clonidine in caudal blocks prolongs postoperative pain relief in children and is safe alternative to bupivacaine alone in paediatric daycare surgeries. Medknow Publications 2009-08 /pmc/articles/PMC2894500/ /pubmed/20640207 Text en © Indian Journal of Anaesthesia http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Koul, Archna
Pant, Deepanjali
Sood, Jayshree
Caudal Clonidine in Day-Care Paediatric Surgery
title Caudal Clonidine in Day-Care Paediatric Surgery
title_full Caudal Clonidine in Day-Care Paediatric Surgery
title_fullStr Caudal Clonidine in Day-Care Paediatric Surgery
title_full_unstemmed Caudal Clonidine in Day-Care Paediatric Surgery
title_short Caudal Clonidine in Day-Care Paediatric Surgery
title_sort caudal clonidine in day-care paediatric surgery
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894500/
https://www.ncbi.nlm.nih.gov/pubmed/20640207
work_keys_str_mv AT koularchna caudalclonidineindaycarepaediatricsurgery
AT pantdeepanjali caudalclonidineindaycarepaediatricsurgery
AT soodjayshree caudalclonidineindaycarepaediatricsurgery