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GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons

BACKGROUND: Gangliosides, sialic acid-containing glycosphingolipids exist in mammalian cell membranes particularly neuronal membranes. The trisialoganglioside (GT1b) is one of the major brain gangliosides and acts as an endogenous regulator in the brain. We previously showed GT1b induces mesencephal...

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Detalles Bibliográficos
Autores principales:	Chung, Eun S, Bok, Eugene, Sohn, Sunghyang, Lee, Young D, Baik, Hyung H, Jin, Byung K
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894844/ https://www.ncbi.nlm.nih.gov/pubmed/20540782 http://dx.doi.org/10.1186/1471-2202-11-74

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