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Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features
During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the ra...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894881/ https://www.ncbi.nlm.nih.gov/pubmed/20613979 http://dx.doi.org/10.1371/journal.pone.0011398 |
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author | Thaunat, Olivier Graff-Dubois, Stéphanie Brouard, Sophie Gautreau, Chantal Varthaman, Aditi Fabien, Nicole Field, Anne-Christine Louedec, Liliane Dai, Jianping Joly, Etienne Morelon, Emmanuel Soulillou, Jean-Paul Michel, Jean-Baptiste Nicoletti, Antonino |
author_facet | Thaunat, Olivier Graff-Dubois, Stéphanie Brouard, Sophie Gautreau, Chantal Varthaman, Aditi Fabien, Nicole Field, Anne-Christine Louedec, Liliane Dai, Jianping Joly, Etienne Morelon, Emmanuel Soulillou, Jean-Paul Michel, Jean-Baptiste Nicoletti, Antonino |
author_sort | Thaunat, Olivier |
collection | PubMed |
description | During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation. The immune responses elicited in adventitial TLT and those taking place in spleen and draining lymph nodes (LN) were compared in terms of antibody production, T cell activation and repertoire perturbations. The anti-MHC humoral response was more intense and more diverse in TLT. This difference was associated with an increased percentage of activated CD4+ T cells and a symmetric reduction of regulatory T cell subsets. Moreover, TCR repertoire perturbations in TLT were not only increased and different from the common pattern observed in spleen and LN but also “stochastic,” since each recipient displayed a specific pattern. We propose that the abnormal activation of CD4+ T cells promotes the development of an exaggerated pathogenic immune humoral response in TLT. Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts. |
format | Text |
id | pubmed-2894881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28948812010-07-07 Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features Thaunat, Olivier Graff-Dubois, Stéphanie Brouard, Sophie Gautreau, Chantal Varthaman, Aditi Fabien, Nicole Field, Anne-Christine Louedec, Liliane Dai, Jianping Joly, Etienne Morelon, Emmanuel Soulillou, Jean-Paul Michel, Jean-Baptiste Nicoletti, Antonino PLoS One Research Article During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation. The immune responses elicited in adventitial TLT and those taking place in spleen and draining lymph nodes (LN) were compared in terms of antibody production, T cell activation and repertoire perturbations. The anti-MHC humoral response was more intense and more diverse in TLT. This difference was associated with an increased percentage of activated CD4+ T cells and a symmetric reduction of regulatory T cell subsets. Moreover, TCR repertoire perturbations in TLT were not only increased and different from the common pattern observed in spleen and LN but also “stochastic,” since each recipient displayed a specific pattern. We propose that the abnormal activation of CD4+ T cells promotes the development of an exaggerated pathogenic immune humoral response in TLT. Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts. Public Library of Science 2010-06-30 /pmc/articles/PMC2894881/ /pubmed/20613979 http://dx.doi.org/10.1371/journal.pone.0011398 Text en Thaunat et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Thaunat, Olivier Graff-Dubois, Stéphanie Brouard, Sophie Gautreau, Chantal Varthaman, Aditi Fabien, Nicole Field, Anne-Christine Louedec, Liliane Dai, Jianping Joly, Etienne Morelon, Emmanuel Soulillou, Jean-Paul Michel, Jean-Baptiste Nicoletti, Antonino Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features |
title | Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features |
title_full | Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features |
title_fullStr | Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features |
title_full_unstemmed | Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features |
title_short | Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features |
title_sort | immune responses elicited in tertiary lymphoid tissues display distinctive features |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894881/ https://www.ncbi.nlm.nih.gov/pubmed/20613979 http://dx.doi.org/10.1371/journal.pone.0011398 |
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