UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

BACKGROUND: The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. METHODOLOGY/PRINCIPAL FINDINGS: Here we report that cyclooxygenase (COX) activity and prostaglandin E(2) (PGE(2)) are crucially involved in induction of UCP1 expression...

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Detalles Bibliográficos
Autores principales: Madsen, Lise, Pedersen, Lone M., Lillefosse, Haldis Haukaas, Fjære, Even, Bronstad, Ingeborg, Hao, Qin, Petersen, Rasmus K., Hallenborg, Philip, Ma, Tao, De Matteis, Rita, Araujo, Pedro, Mercader, Josep, Bonet, M. Luisa, Hansen, Jacob B., Cannon, Barbara, Nedergaard, Jan, Wang, Jun, Cinti, Saverio, Voshol, Peter, Døskeland, Stein Ove, Kristiansen, Karsten
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894971/
https://www.ncbi.nlm.nih.gov/pubmed/20613988
http://dx.doi.org/10.1371/journal.pone.0011391

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