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Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series
Marantic endocarditis, otherwise known as nonbacterial thrombotic endocarditis (NBTE), is a well-documented phenomenon due to hypercoagulability from an underlying cause. It has been associated with a variety of inflammatory states including malignancy. Surprisingly, although hypercoagulability is o...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895179/ https://www.ncbi.nlm.nih.gov/pubmed/20651968 http://dx.doi.org/10.1159/000207195 |
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author | Jameson, Gayle S. Ramanathan, Ramesh K. Borad, Mitesh J. Downhour, Molly Korn, Ronald Von Hoff, Daniel |
author_facet | Jameson, Gayle S. Ramanathan, Ramesh K. Borad, Mitesh J. Downhour, Molly Korn, Ronald Von Hoff, Daniel |
author_sort | Jameson, Gayle S. |
collection | PubMed |
description | Marantic endocarditis, otherwise known as nonbacterial thrombotic endocarditis (NBTE), is a well-documented phenomenon due to hypercoagulability from an underlying cause. It has been associated with a variety of inflammatory states including malignancy. Surprisingly, although hypercoagulability is often seen in patients with pancreatic cancer, marantic endocarditis has rarely been reported antemortem in this population. We report three cases of marantic endocarditis in patients with advanced pancreatic cancer. In two instances, the patients’ neurological symptoms preceded the diagnosis of advanced pancreatic cancer. Health care professionals should be alert to the possibility of marantic endocarditis in any patient with cancer, especially pancreatic cancer, who presents with symptoms of neurological dysfunction or an arterial thrombotic event. Prompt diagnosis and treatment with heparin, unfractionated or low molecular weight, may prevent catastrophic CNS events and decrease morbidity in patients with pancreatic cancer and other malignancies. |
format | Text |
id | pubmed-2895179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-28951792010-07-22 Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series Jameson, Gayle S. Ramanathan, Ramesh K. Borad, Mitesh J. Downhour, Molly Korn, Ronald Von Hoff, Daniel Case Rep Gastroenterol Published: April 2009 Marantic endocarditis, otherwise known as nonbacterial thrombotic endocarditis (NBTE), is a well-documented phenomenon due to hypercoagulability from an underlying cause. It has been associated with a variety of inflammatory states including malignancy. Surprisingly, although hypercoagulability is often seen in patients with pancreatic cancer, marantic endocarditis has rarely been reported antemortem in this population. We report three cases of marantic endocarditis in patients with advanced pancreatic cancer. In two instances, the patients’ neurological symptoms preceded the diagnosis of advanced pancreatic cancer. Health care professionals should be alert to the possibility of marantic endocarditis in any patient with cancer, especially pancreatic cancer, who presents with symptoms of neurological dysfunction or an arterial thrombotic event. Prompt diagnosis and treatment with heparin, unfractionated or low molecular weight, may prevent catastrophic CNS events and decrease morbidity in patients with pancreatic cancer and other malignancies. S. Karger AG 2009-04-15 /pmc/articles/PMC2895179/ /pubmed/20651968 http://dx.doi.org/10.1159/000207195 Text en Copyright © 2009 by S. Karger AG, Basel |
spellingShingle | Published: April 2009 Jameson, Gayle S. Ramanathan, Ramesh K. Borad, Mitesh J. Downhour, Molly Korn, Ronald Von Hoff, Daniel Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series |
title | Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series |
title_full | Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series |
title_fullStr | Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series |
title_full_unstemmed | Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series |
title_short | Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series |
title_sort | marantic endocarditis associated with pancreatic cancer: a case series |
topic | Published: April 2009 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895179/ https://www.ncbi.nlm.nih.gov/pubmed/20651968 http://dx.doi.org/10.1159/000207195 |
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