Assessing the human immune system through blood transcriptomics

Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and...

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Detalles Bibliográficos
Autores principales: Chaussabel, Damien, Pascual, Virginia, Banchereau, Jacques
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895587/
https://www.ncbi.nlm.nih.gov/pubmed/20619006
http://dx.doi.org/10.1186/1741-7007-8-84
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author Chaussabel, Damien
Pascual, Virginia
Banchereau, Jacques
author_facet Chaussabel, Damien
Pascual, Virginia
Banchereau, Jacques
author_sort Chaussabel, Damien
collection PubMed
description Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed.
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spelling pubmed-28955872010-07-02 Assessing the human immune system through blood transcriptomics Chaussabel, Damien Pascual, Virginia Banchereau, Jacques BMC Biol Review Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed. BioMed Central 2010-07-01 /pmc/articles/PMC2895587/ /pubmed/20619006 http://dx.doi.org/10.1186/1741-7007-8-84 Text en Copyright ©2010 Chaussabel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chaussabel, Damien
Pascual, Virginia
Banchereau, Jacques
Assessing the human immune system through blood transcriptomics
title Assessing the human immune system through blood transcriptomics
title_full Assessing the human immune system through blood transcriptomics
title_fullStr Assessing the human immune system through blood transcriptomics
title_full_unstemmed Assessing the human immune system through blood transcriptomics
title_short Assessing the human immune system through blood transcriptomics
title_sort assessing the human immune system through blood transcriptomics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895587/
https://www.ncbi.nlm.nih.gov/pubmed/20619006
http://dx.doi.org/10.1186/1741-7007-8-84
work_keys_str_mv AT chaussabeldamien assessingthehumanimmunesystemthroughbloodtranscriptomics
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AT banchereaujacques assessingthehumanimmunesystemthroughbloodtranscriptomics

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