Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid

BACKGROUND: Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. Lysophosphatidic acid (LPA), autotaxin (ATX), the enzyme that produces LPA, and the LPA recep...

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Detalles Bibliográficos
Autores principales: Altman, Molly K, Gopal, Vashisht, Jia, Wei, Yu, Shuangxing, Hall, Hassan, Mills, Gordon B, McGinnis, A Cary, Bartlett, Michael G, Jiang, Guowei, Madan, Damian, Prestwich, Glenn D, Xu, Yong, Davies, Michael A, Murph, Mandi M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895597/
https://www.ncbi.nlm.nih.gov/pubmed/20529378
http://dx.doi.org/10.1186/1476-4598-9-140

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