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Conductance Ratios and Cellular Identity

Recent experimental evidence suggests that coordinated expression of ion channels plays a role in constraining neuronal electrical activity. In particular, each neuronal cell type of the crustacean stomatogastric ganglion exhibits a unique set of positive linear correlations between ionic membrane c...

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Detalles Bibliográficos
Autores principales: Hudson, Amber E., Prinz, Astrid A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895636/
https://www.ncbi.nlm.nih.gov/pubmed/20628472
http://dx.doi.org/10.1371/journal.pcbi.1000838
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author Hudson, Amber E.
Prinz, Astrid A.
author_facet Hudson, Amber E.
Prinz, Astrid A.
author_sort Hudson, Amber E.
collection PubMed
description Recent experimental evidence suggests that coordinated expression of ion channels plays a role in constraining neuronal electrical activity. In particular, each neuronal cell type of the crustacean stomatogastric ganglion exhibits a unique set of positive linear correlations between ionic membrane conductances. These data suggest a causal relationship between expressed conductance correlations and features of cellular identity, namely electrical activity type. To test this idea, we used an existing database of conductance-based model neurons. We partitioned this database based on various measures of intrinsic activity, to approximate distinctions between biological cell types. We then tested individual conductance pairs for linear dependence to identify correlations. Contrary to experimental evidence, in which all conductance correlations are positive, 32% of correlations seen in this database were negative relationships. In addition, 80% of correlations seen here involved at least one calcium conductance, which have been difficult to measure experimentally. Similar to experimental results, each activity type investigated had a unique combination of correlated conductances. Finally, we found that populations of models that conform to a specific conductance correlation have a higher likelihood of exhibiting a particular feature of electrical activity. We conclude that regulating conductance ratios can support proper electrical activity of a wide range of cell types, particularly when the identity of the cell is well-defined by one or two features of its activity. Furthermore, we predict that previously unseen negative correlations and correlations involving calcium conductances are biologically plausible.
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spelling pubmed-28956362010-07-13 Conductance Ratios and Cellular Identity Hudson, Amber E. Prinz, Astrid A. PLoS Comput Biol Research Article Recent experimental evidence suggests that coordinated expression of ion channels plays a role in constraining neuronal electrical activity. In particular, each neuronal cell type of the crustacean stomatogastric ganglion exhibits a unique set of positive linear correlations between ionic membrane conductances. These data suggest a causal relationship between expressed conductance correlations and features of cellular identity, namely electrical activity type. To test this idea, we used an existing database of conductance-based model neurons. We partitioned this database based on various measures of intrinsic activity, to approximate distinctions between biological cell types. We then tested individual conductance pairs for linear dependence to identify correlations. Contrary to experimental evidence, in which all conductance correlations are positive, 32% of correlations seen in this database were negative relationships. In addition, 80% of correlations seen here involved at least one calcium conductance, which have been difficult to measure experimentally. Similar to experimental results, each activity type investigated had a unique combination of correlated conductances. Finally, we found that populations of models that conform to a specific conductance correlation have a higher likelihood of exhibiting a particular feature of electrical activity. We conclude that regulating conductance ratios can support proper electrical activity of a wide range of cell types, particularly when the identity of the cell is well-defined by one or two features of its activity. Furthermore, we predict that previously unseen negative correlations and correlations involving calcium conductances are biologically plausible. Public Library of Science 2010-07-01 /pmc/articles/PMC2895636/ /pubmed/20628472 http://dx.doi.org/10.1371/journal.pcbi.1000838 Text en Hudson, Prinz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hudson, Amber E.
Prinz, Astrid A.
Conductance Ratios and Cellular Identity
title Conductance Ratios and Cellular Identity
title_full Conductance Ratios and Cellular Identity
title_fullStr Conductance Ratios and Cellular Identity
title_full_unstemmed Conductance Ratios and Cellular Identity
title_short Conductance Ratios and Cellular Identity
title_sort conductance ratios and cellular identity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895636/
https://www.ncbi.nlm.nih.gov/pubmed/20628472
http://dx.doi.org/10.1371/journal.pcbi.1000838
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