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Adaptive Evolution of Mus Apobec3 Includes Retroviral Insertion and Positive Selection at Two Clusters of Residues Flanking the Substrate Groove

Mouse APOBEC3 (mA3) is a cytidine deaminase with antiviral activity. mA3 is linked to the Rfv3 virus resistance factor, a gene responsible for recovery from infection by Friend murine leukemia virus, and mA3 allelic variants differ in their ability to restrict mouse mammary tumor virus. We sequenced...

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Detalles Bibliográficos
Autores principales:	Sanville, Bradley, Dolan, Michael A., Wollenberg, Kurt, Yan, Yuhe, Martin, Carrie, Yeung, Man Lung, Strebel, Klaus, Buckler-White, Alicia, Kozak, Christine A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895647/ https://www.ncbi.nlm.nih.gov/pubmed/20617165 http://dx.doi.org/10.1371/journal.ppat.1000974

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