Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility

Despite the central role of estrogen exposure in breast and endometrial cancer development and numerous studies of genes in the estrogen metabolic pathway, polymorphisms within the pathway have not been consistently associated with these cancers. We posit that this is due to the complexity of multip...

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Detalles Bibliográficos
Autores principales: Low, Yen Ling, Li, Yuqing, Humphreys, Keith, Thalamuthu, Anbupalam, Li, Yi, Darabi, Hatef, Wedrén, Sara, Bonnard, Carine, Czene, Kamila, Iles, Mark M., Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Hall, Per, Liu, Edison T., Liu, Jianjun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895650/
https://www.ncbi.nlm.nih.gov/pubmed/20617168
http://dx.doi.org/10.1371/journal.pgen.1001012

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