Cargando…
Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation
BACKGROUND: Radiotherapy kills tumor-cells by inducing DNA double strand breaks (DSBs). However, the efficient repair of tumors frequently prevents successful treatment. Therefore, identifying new practical sensitizers is an essential step towards successful radiotherapy. In this study, we tested th...
Autores principales: | Yan, Dan, Ng, Wooi Loon, Zhang, Xiangming, Wang, Ping, Zhang, Zhaobin, Mo, Yin-Yuan, Mao, Hui, Hao, Chunhai, Olson, Jeffrey J., Curran, Walter J., Wang, Ya |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895662/ https://www.ncbi.nlm.nih.gov/pubmed/20617180 http://dx.doi.org/10.1371/journal.pone.0011397 |
Ejemplares similares
-
ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022) -
DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism
por: Chen, Wei‐Min, et al.
Publicado: (2023) -
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
por: Caron, Pierre, et al.
Publicado: (2015) -
ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
por: Menolfi, Demis, et al.
Publicado: (2020) -
Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G(2)-phase
por: Mladenov, Emil, et al.
Publicado: (2019)