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Ultra-Fast Analysis of Plasma and Intracellular Levels of HIV Protease Inhibitors in Children: A Clinical Application of MALDI Mass Spectrometry

HIV protease inhibitors must penetrate into cells to exert their action. Differences in the intracellular pharmacokinetics of these drugs may explain why some patients fail on therapy or suffer from drug toxicity. Yet, there is no information available on the intracellular levels of HIV protease inh...

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Detalles Bibliográficos
Autores principales:	van Kampen, Jeroen J. A., Reedijk, Mariska L., Burgers, Peter C., Dekker, Lennard J. M., Hartwig, Nico G., van der Ende, Ineke E., de Groot, Ronald, Osterhaus, Albert D. M. E., Burger, David M., Luider, Theo M., Gruters, Rob A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895665/ https://www.ncbi.nlm.nih.gov/pubmed/20625386 http://dx.doi.org/10.1371/journal.pone.0011409

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