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Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrP(Sc)

While elucidating the peculiar epitope of the α-PrP mAb IPC2, we found that PrP(Sc) exhibits the sulfoxidation of residue M213 as a covalent signature. Subsequent computational analysis predicted that the presence of sulfoxide groups at both Met residues 206 and 213 destabilize the α-fold, suggestin...

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Detalles Bibliográficos
Autores principales:	Canello, Tamar, Frid, Kati, Gabizon, Ronen, Lisa, Silvia, Friedler, Assaf, Moskovitz, Jackob, Gasset, María, Gabizon, Ruth
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895666/ https://www.ncbi.nlm.nih.gov/pubmed/20625387 http://dx.doi.org/10.1371/journal.ppat.1000977

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