Cargando…
The dual kinase complex FAK-Src as a promising therapeutic target in cancer
Focal adhesion kinase (FAK) and steroid receptor coactivator (Src) are intracellular (nonreceptor) tyrosine kinases that physically and functionally interact to promote a variety of cellular responses. Plenty of reports have already suggested an additional central role for this complex in cancer thr...
Autores principales: | Bolós, Victoria, Gasent, Joan Manuel, López-Tarruella, Sara, Grande, Enrique |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895777/ https://www.ncbi.nlm.nih.gov/pubmed/20616959 |
Ejemplares similares
-
Multiple roles and therapeutic implications of Akt signaling in cancer
por: Calvo, Emiliano, et al.
Publicado: (2009) -
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
por: Horton, Edward R., et al.
Publicado: (2016) -
Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma
por: van Erp, Anke E. M., et al.
Publicado: (2022) -
Dissociation of FAK/p130(CAS)/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK
por: Yamakita, Yoshihiko, et al.
Publicado: (1999) -
Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)