Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m(7)G methyltransferases

Sgm (Sisomicin-gentamicin methyltransferase) from antibiotic-producing bacterium Micromonospora zionensis is an enzyme that confers resistance to aminoglycosides like gentamicin and sisomicin by specifically methylating G1405 in bacterial 16S rRNA. Sgm belongs to the aminoglycoside resistance methyl...

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Detalles Bibliográficos
Autores principales: Husain, Nilofer, Tkaczuk, Karolina L., Tulsidas, Shenoy Rajesh, Kaminska, Katarzyna H., Čubrilo, Sonja, Maravić-Vlahoviček, Gordana, Bujnicki, Janusz M., Sivaraman, J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896518/
https://www.ncbi.nlm.nih.gov/pubmed/20194115
http://dx.doi.org/10.1093/nar/gkq122

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