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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

A balanced supply of deoxyribonucleoside triphosphates (dNTPs) is one of the key prerequisites for faithful genome duplication. Both the overall concentration and the balance among the individual dNTPs (dATP, dTTP, dGTP, and dCTP) are tightly regulated, primarily by the enzyme ribonucleotide reducta...

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Detalles Bibliográficos
Autores principales:	Kumar, Dinesh, Viberg, Jörgen, Nilsson, Anna Karin, Chabes, Andrei
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896522/ https://www.ncbi.nlm.nih.gov/pubmed/20215435 http://dx.doi.org/10.1093/nar/gkq128

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