Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA

Rpp20 and Rpp25 are two key subunits of the human endoribonucleases RNase P and MRP. Formation of an Rpp20–Rpp25 complex is critical for enzyme function and sub-cellular localization. We present the first detailed in vitro analysis of their conformational properties, and a biochemical and biophysica...

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Detalles Bibliográficos
Autores principales: Hands-Taylor, Katherine L. D., Martino, Luigi, Tata, Renée, Babon, Jeffrey J., Bui, Tam T., Drake, Alex F., Beavil, Rebecca L., Pruijn, Ger J. M., Brown, Paul R., Conte, Maria R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896528/
https://www.ncbi.nlm.nih.gov/pubmed/20215441
http://dx.doi.org/10.1093/nar/gkq141

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