Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase

WRN protein loss causes Werner syndrome (WS), which is characterized by premature aging as well as genomic and telomeric instability. WRN prevents telomere loss, but the telomeric protein complex must regulate WRN activities to prevent aberrant telomere processing. Telomere-binding TRF2 protein inhi...

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Detalles Bibliográficos
Autores principales: Nora, Gerald J., Buncher, Noah A., Opresko, Patricia L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896529/
https://www.ncbi.nlm.nih.gov/pubmed/20215438
http://dx.doi.org/10.1093/nar/gkq144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896529/
https://www.ncbi.nlm.nih.gov/pubmed/20215438
http://dx.doi.org/10.1093/nar/gkq144

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