Direct Microbicidal Activity of Cytotoxic T-Lymphocytes

Cytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and fungi. Here, we review past and recent finding...

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Detalles Bibliográficos
Autores principales: Oykhman, Paul, Mody, Christopher H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896662/
https://www.ncbi.nlm.nih.gov/pubmed/20617144
http://dx.doi.org/10.1155/2010/249482
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author Oykhman, Paul
Mody, Christopher H.
author_facet Oykhman, Paul
Mody, Christopher H.
author_sort Oykhman, Paul
collection PubMed
description Cytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and fungi. Here, we review past and recent findings demonstrating the direct microbicidal activity of both CD4(+) and CD8(+) CTL against various microbial pathogens. Further, this review will outline what is known regarding the mechanisms of direct killing and their underlying signalling pathways.
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spelling pubmed-28966622010-07-08 Direct Microbicidal Activity of Cytotoxic T-Lymphocytes Oykhman, Paul Mody, Christopher H. J Biomed Biotechnol Review Article Cytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and fungi. Here, we review past and recent findings demonstrating the direct microbicidal activity of both CD4(+) and CD8(+) CTL against various microbial pathogens. Further, this review will outline what is known regarding the mechanisms of direct killing and their underlying signalling pathways. Hindawi Publishing Corporation 2010 2010-06-23 /pmc/articles/PMC2896662/ /pubmed/20617144 http://dx.doi.org/10.1155/2010/249482 Text en Copyright © 2010 P. Oykhman and C. H. Mody. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oykhman, Paul
Mody, Christopher H.
Direct Microbicidal Activity of Cytotoxic T-Lymphocytes
title Direct Microbicidal Activity of Cytotoxic T-Lymphocytes
title_full Direct Microbicidal Activity of Cytotoxic T-Lymphocytes
title_fullStr Direct Microbicidal Activity of Cytotoxic T-Lymphocytes
title_full_unstemmed Direct Microbicidal Activity of Cytotoxic T-Lymphocytes
title_short Direct Microbicidal Activity of Cytotoxic T-Lymphocytes
title_sort direct microbicidal activity of cytotoxic t-lymphocytes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896662/
https://www.ncbi.nlm.nih.gov/pubmed/20617144
http://dx.doi.org/10.1155/2010/249482
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AT modychristopherh directmicrobicidalactivityofcytotoxictlymphocytes

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