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Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans

Effective immunotherapy for cancer depends on cellular responses to tumor antigens. The role of major histocompatibility complex (MHC) in T-cell recognition and T-cell receptor repertoire selection has become a central tenet in immunology. Structurally, this does not contradict earlier findings that...

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Autores principales: Pashov, Anastas, Monzavi-Karbassi, Bejatolah, Raghava, Gajendra P. S., Kieber-Emmons, Thomas
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896669/
https://www.ncbi.nlm.nih.gov/pubmed/20617150
http://dx.doi.org/10.1155/2010/354068
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author Pashov, Anastas
Monzavi-Karbassi, Bejatolah
Raghava, Gajendra P. S.
Kieber-Emmons, Thomas
author_facet Pashov, Anastas
Monzavi-Karbassi, Bejatolah
Raghava, Gajendra P. S.
Kieber-Emmons, Thomas
author_sort Pashov, Anastas
collection PubMed
description Effective immunotherapy for cancer depends on cellular responses to tumor antigens. The role of major histocompatibility complex (MHC) in T-cell recognition and T-cell receptor repertoire selection has become a central tenet in immunology. Structurally, this does not contradict earlier findings that T-cells can differentiate between small hapten structures like simple glycans. Understanding T-cell recognition of antigens as defined genetically by MHC and combinatorially by T cell receptors led to the “altered self” hypothesis. This notion reflects a more fundamental principle underlying immune surveillance and integrating evolutionarily and mechanistically diverse elements of the immune system. Danger associated molecular patterns, including those generated by glycan remodeling, represent an instance of altered self. A prominent example is the modification of the tumor-associated antigen MUC1. Similar examples emphasize glycan reactivity patterns of antigen receptors as a phenomenon bridging innate and adaptive but also humoral and cellular immunity and providing templates for immunotherapies.
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spelling pubmed-28966692010-07-08 Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans Pashov, Anastas Monzavi-Karbassi, Bejatolah Raghava, Gajendra P. S. Kieber-Emmons, Thomas J Biomed Biotechnol Review Article Effective immunotherapy for cancer depends on cellular responses to tumor antigens. The role of major histocompatibility complex (MHC) in T-cell recognition and T-cell receptor repertoire selection has become a central tenet in immunology. Structurally, this does not contradict earlier findings that T-cells can differentiate between small hapten structures like simple glycans. Understanding T-cell recognition of antigens as defined genetically by MHC and combinatorially by T cell receptors led to the “altered self” hypothesis. This notion reflects a more fundamental principle underlying immune surveillance and integrating evolutionarily and mechanistically diverse elements of the immune system. Danger associated molecular patterns, including those generated by glycan remodeling, represent an instance of altered self. A prominent example is the modification of the tumor-associated antigen MUC1. Similar examples emphasize glycan reactivity patterns of antigen receptors as a phenomenon bridging innate and adaptive but also humoral and cellular immunity and providing templates for immunotherapies. Hindawi Publishing Corporation 2010 2010-06-15 /pmc/articles/PMC2896669/ /pubmed/20617150 http://dx.doi.org/10.1155/2010/354068 Text en Copyright © 2010 Anastas Pashov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pashov, Anastas
Monzavi-Karbassi, Bejatolah
Raghava, Gajendra P. S.
Kieber-Emmons, Thomas
Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans
title Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans
title_full Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans
title_fullStr Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans
title_full_unstemmed Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans
title_short Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans
title_sort bridging innate and adaptive antitumor immunity targeting glycans
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896669/
https://www.ncbi.nlm.nih.gov/pubmed/20617150
http://dx.doi.org/10.1155/2010/354068
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