A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis

For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, neces...

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Autores principales: Momose, Haruka, Mizukami, Takuo, Ochiai, Masaki, Hamaguchi, Isao, Yamaguchi, Kazunari
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896671/
https://www.ncbi.nlm.nih.gov/pubmed/20617152
http://dx.doi.org/10.1155/2010/361841
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author Momose, Haruka
Mizukami, Takuo
Ochiai, Masaki
Hamaguchi, Isao
Yamaguchi, Kazunari
author_facet Momose, Haruka
Mizukami, Takuo
Ochiai, Masaki
Hamaguchi, Isao
Yamaguchi, Kazunari
author_sort Momose, Haruka
collection PubMed
description For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.
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spelling pubmed-28966712010-07-08 A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis Momose, Haruka Mizukami, Takuo Ochiai, Masaki Hamaguchi, Isao Yamaguchi, Kazunari J Biomed Biotechnol Review Article For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity. Hindawi Publishing Corporation 2010 2010-06-13 /pmc/articles/PMC2896671/ /pubmed/20617152 http://dx.doi.org/10.1155/2010/361841 Text en Copyright © 2010 Haruka Momose et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Momose, Haruka
Mizukami, Takuo
Ochiai, Masaki
Hamaguchi, Isao
Yamaguchi, Kazunari
A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_full A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_fullStr A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_full_unstemmed A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_short A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_sort new method for the evaluation of vaccine safety based on comprehensive gene expression analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896671/
https://www.ncbi.nlm.nih.gov/pubmed/20617152
http://dx.doi.org/10.1155/2010/361841
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