Roles of Titin in the Structure and Elasticity of the Sarcomere

The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest len...

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Detalles Bibliográficos
Autores principales: Tskhovrebova, Larissa, Trinick, John
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896707/
https://www.ncbi.nlm.nih.gov/pubmed/20625501
http://dx.doi.org/10.1155/2010/612482
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author Tskhovrebova, Larissa
Trinick, John
author_facet Tskhovrebova, Larissa
Trinick, John
author_sort Tskhovrebova, Larissa
collection PubMed
description The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest length, its operating range of lengths, and passive elastic properties are also directly controlled by the properties of titin. Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity.
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spelling pubmed-28967072010-07-12 Roles of Titin in the Structure and Elasticity of the Sarcomere Tskhovrebova, Larissa Trinick, John J Biomed Biotechnol Review Article The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest length, its operating range of lengths, and passive elastic properties are also directly controlled by the properties of titin. Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity. Hindawi Publishing Corporation 2010 2010-06-21 /pmc/articles/PMC2896707/ /pubmed/20625501 http://dx.doi.org/10.1155/2010/612482 Text en Copyright © 2010 L. Tskhovrebova and J. Trinick. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tskhovrebova, Larissa
Trinick, John
Roles of Titin in the Structure and Elasticity of the Sarcomere
title Roles of Titin in the Structure and Elasticity of the Sarcomere
title_full Roles of Titin in the Structure and Elasticity of the Sarcomere
title_fullStr Roles of Titin in the Structure and Elasticity of the Sarcomere
title_full_unstemmed Roles of Titin in the Structure and Elasticity of the Sarcomere
title_short Roles of Titin in the Structure and Elasticity of the Sarcomere
title_sort roles of titin in the structure and elasticity of the sarcomere
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896707/
https://www.ncbi.nlm.nih.gov/pubmed/20625501
http://dx.doi.org/10.1155/2010/612482
work_keys_str_mv AT tskhovrebovalarissa rolesoftitininthestructureandelasticityofthesarcomere
AT trinickjohn rolesoftitininthestructureandelasticityofthesarcomere

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