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A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment

The human red blood cell (RBC) has long been used for modeling of complex biological networks, for elucidation of a wide variety of dynamic phenomena, and for understanding the fundamental topology of metabolic pathways. Here, we introduce our recent work on an RBC metabolic model using the E-Cell S...

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Detalles Bibliográficos
Autores principales: Yachie-Kinoshita, Ayako, Nishino, Taiko, Shimo, Hanae, Suematsu, Makoto, Tomita, Masaru
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896712/
https://www.ncbi.nlm.nih.gov/pubmed/20625505
http://dx.doi.org/10.1155/2010/642420
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author Yachie-Kinoshita, Ayako
Nishino, Taiko
Shimo, Hanae
Suematsu, Makoto
Tomita, Masaru
author_facet Yachie-Kinoshita, Ayako
Nishino, Taiko
Shimo, Hanae
Suematsu, Makoto
Tomita, Masaru
author_sort Yachie-Kinoshita, Ayako
collection PubMed
description The human red blood cell (RBC) has long been used for modeling of complex biological networks, for elucidation of a wide variety of dynamic phenomena, and for understanding the fundamental topology of metabolic pathways. Here, we introduce our recent work on an RBC metabolic model using the E-Cell Simulation Environment. The model is sufficiently detailed to predict the temporal hypoxic response of each metabolite and, at the same time, successfully integrates modulation of metabolism and of the oxygen transporting capacity of hemoglobin. The model includes the mechanisms of RBC maintenance as a single cell system and the functioning of RBCs as components of a higher order system. Modeling of RBC metabolism is now approaching a fully mature stage of realistic predictions at the molecular level and will be useful for predicting conditions in biotechnological applications such as long-term cold storage of RBCs.
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spelling pubmed-28967122010-07-12 A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment Yachie-Kinoshita, Ayako Nishino, Taiko Shimo, Hanae Suematsu, Makoto Tomita, Masaru J Biomed Biotechnol Review Article The human red blood cell (RBC) has long been used for modeling of complex biological networks, for elucidation of a wide variety of dynamic phenomena, and for understanding the fundamental topology of metabolic pathways. Here, we introduce our recent work on an RBC metabolic model using the E-Cell Simulation Environment. The model is sufficiently detailed to predict the temporal hypoxic response of each metabolite and, at the same time, successfully integrates modulation of metabolism and of the oxygen transporting capacity of hemoglobin. The model includes the mechanisms of RBC maintenance as a single cell system and the functioning of RBCs as components of a higher order system. Modeling of RBC metabolism is now approaching a fully mature stage of realistic predictions at the molecular level and will be useful for predicting conditions in biotechnological applications such as long-term cold storage of RBCs. Hindawi Publishing Corporation 2010 2010-06-28 /pmc/articles/PMC2896712/ /pubmed/20625505 http://dx.doi.org/10.1155/2010/642420 Text en Copyright © 2010 Ayako Yachie-Kinoshita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yachie-Kinoshita, Ayako
Nishino, Taiko
Shimo, Hanae
Suematsu, Makoto
Tomita, Masaru
A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
title A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
title_full A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
title_fullStr A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
title_full_unstemmed A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
title_short A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
title_sort metabolic model of human erythrocytes: practical application of the e-cell simulation environment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896712/
https://www.ncbi.nlm.nih.gov/pubmed/20625505
http://dx.doi.org/10.1155/2010/642420
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