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Therapeutic Cancer Vaccines in Combination with Conventional Therapy

The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination with che...

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Autores principales: Andersen, Mads Hald, Junker, Niels, Ellebaek, Eva, Svane, Inge Marie, thor Straten, Per
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896846/
https://www.ncbi.nlm.nih.gov/pubmed/20617155
http://dx.doi.org/10.1155/2010/237623
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author Andersen, Mads Hald
Junker, Niels
Ellebaek, Eva
Svane, Inge Marie
thor Straten, Per
author_facet Andersen, Mads Hald
Junker, Niels
Ellebaek, Eva
Svane, Inge Marie
thor Straten, Per
author_sort Andersen, Mads Hald
collection PubMed
description The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination with chemotherapy may lead to improved clinical efficacy by clearing suppressor cells, reboot of the immune system, by rendering tumor cells more susceptible to immune mediated killing, or by activation of cells of the immune system. In addition, a range of tumor antigens have been characterized to allow targeting of proteins coupled to intrinsic properties of cancer cells. For example, proteins associated with drug resistance can be targeted, and form ideal target structures for use in combination with chemotherapy for killing of surviving drug resistant cancer cells. Proteins associated with the malignant phenotype can be targeted to specifically target cancer cells, but proteins targeted by immunotherapy may also simultaneously target cancer cells as well as suppressive cells in the tumor stroma.
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spelling pubmed-28968462010-07-08 Therapeutic Cancer Vaccines in Combination with Conventional Therapy Andersen, Mads Hald Junker, Niels Ellebaek, Eva Svane, Inge Marie thor Straten, Per J Biomed Biotechnol Review Article The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination with chemotherapy may lead to improved clinical efficacy by clearing suppressor cells, reboot of the immune system, by rendering tumor cells more susceptible to immune mediated killing, or by activation of cells of the immune system. In addition, a range of tumor antigens have been characterized to allow targeting of proteins coupled to intrinsic properties of cancer cells. For example, proteins associated with drug resistance can be targeted, and form ideal target structures for use in combination with chemotherapy for killing of surviving drug resistant cancer cells. Proteins associated with the malignant phenotype can be targeted to specifically target cancer cells, but proteins targeted by immunotherapy may also simultaneously target cancer cells as well as suppressive cells in the tumor stroma. Hindawi Publishing Corporation 2010 2010-06-29 /pmc/articles/PMC2896846/ /pubmed/20617155 http://dx.doi.org/10.1155/2010/237623 Text en Copyright © 2010 Mads Hald Andersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Andersen, Mads Hald
Junker, Niels
Ellebaek, Eva
Svane, Inge Marie
thor Straten, Per
Therapeutic Cancer Vaccines in Combination with Conventional Therapy
title Therapeutic Cancer Vaccines in Combination with Conventional Therapy
title_full Therapeutic Cancer Vaccines in Combination with Conventional Therapy
title_fullStr Therapeutic Cancer Vaccines in Combination with Conventional Therapy
title_full_unstemmed Therapeutic Cancer Vaccines in Combination with Conventional Therapy
title_short Therapeutic Cancer Vaccines in Combination with Conventional Therapy
title_sort therapeutic cancer vaccines in combination with conventional therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896846/
https://www.ncbi.nlm.nih.gov/pubmed/20617155
http://dx.doi.org/10.1155/2010/237623
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