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Therapeutic Cancer Vaccines in Combination with Conventional Therapy
The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination with che...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896846/ https://www.ncbi.nlm.nih.gov/pubmed/20617155 http://dx.doi.org/10.1155/2010/237623 |
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author | Andersen, Mads Hald Junker, Niels Ellebaek, Eva Svane, Inge Marie thor Straten, Per |
author_facet | Andersen, Mads Hald Junker, Niels Ellebaek, Eva Svane, Inge Marie thor Straten, Per |
author_sort | Andersen, Mads Hald |
collection | PubMed |
description | The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination with chemotherapy may lead to improved clinical efficacy by clearing suppressor cells, reboot of the immune system, by rendering tumor cells more susceptible to immune mediated killing, or by activation of cells of the immune system. In addition, a range of tumor antigens have been characterized to allow targeting of proteins coupled to intrinsic properties of cancer cells. For example, proteins associated with drug resistance can be targeted, and form ideal target structures for use in combination with chemotherapy for killing of surviving drug resistant cancer cells. Proteins associated with the malignant phenotype can be targeted to specifically target cancer cells, but proteins targeted by immunotherapy may also simultaneously target cancer cells as well as suppressive cells in the tumor stroma. |
format | Text |
id | pubmed-2896846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28968462010-07-08 Therapeutic Cancer Vaccines in Combination with Conventional Therapy Andersen, Mads Hald Junker, Niels Ellebaek, Eva Svane, Inge Marie thor Straten, Per J Biomed Biotechnol Review Article The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination with chemotherapy may lead to improved clinical efficacy by clearing suppressor cells, reboot of the immune system, by rendering tumor cells more susceptible to immune mediated killing, or by activation of cells of the immune system. In addition, a range of tumor antigens have been characterized to allow targeting of proteins coupled to intrinsic properties of cancer cells. For example, proteins associated with drug resistance can be targeted, and form ideal target structures for use in combination with chemotherapy for killing of surviving drug resistant cancer cells. Proteins associated with the malignant phenotype can be targeted to specifically target cancer cells, but proteins targeted by immunotherapy may also simultaneously target cancer cells as well as suppressive cells in the tumor stroma. Hindawi Publishing Corporation 2010 2010-06-29 /pmc/articles/PMC2896846/ /pubmed/20617155 http://dx.doi.org/10.1155/2010/237623 Text en Copyright © 2010 Mads Hald Andersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Andersen, Mads Hald Junker, Niels Ellebaek, Eva Svane, Inge Marie thor Straten, Per Therapeutic Cancer Vaccines in Combination with Conventional Therapy |
title | Therapeutic Cancer Vaccines in Combination with Conventional Therapy |
title_full | Therapeutic Cancer Vaccines in Combination with Conventional Therapy |
title_fullStr | Therapeutic Cancer Vaccines in Combination with Conventional Therapy |
title_full_unstemmed | Therapeutic Cancer Vaccines in Combination with Conventional Therapy |
title_short | Therapeutic Cancer Vaccines in Combination with Conventional Therapy |
title_sort | therapeutic cancer vaccines in combination with conventional therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896846/ https://www.ncbi.nlm.nih.gov/pubmed/20617155 http://dx.doi.org/10.1155/2010/237623 |
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