The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity

IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21...

Descripción completa

Detalles Bibliográficos
Autores principales: Lieberman, Linda A., Tsokos, George C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896881/
https://www.ncbi.nlm.nih.gov/pubmed/20625413
http://dx.doi.org/10.1155/2010/740619
_version_ 1782183400381087744
author Lieberman, Linda A.
Tsokos, George C.
author_facet Lieberman, Linda A.
Tsokos, George C.
author_sort Lieberman, Linda A.
collection PubMed
description IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased T(reg) production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.
format Text
id pubmed-2896881
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-28968812010-07-12 The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity Lieberman, Linda A. Tsokos, George C. J Biomed Biotechnol Review Article IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased T(reg) production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease. Hindawi Publishing Corporation 2010 2010-06-06 /pmc/articles/PMC2896881/ /pubmed/20625413 http://dx.doi.org/10.1155/2010/740619 Text en Copyright © 2010 L. A. Lieberman and G. C. Tsokos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lieberman, Linda A.
Tsokos, George C.
The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
title The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
title_full The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
title_fullStr The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
title_full_unstemmed The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
title_short The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
title_sort il-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896881/
https://www.ncbi.nlm.nih.gov/pubmed/20625413
http://dx.doi.org/10.1155/2010/740619
work_keys_str_mv AT liebermanlindaa theil2defectinsystemiclupuserythematosusdiseasehasanexpansiveeffectonhostimmunity
AT tsokosgeorgec theil2defectinsystemiclupuserythematosusdiseasehasanexpansiveeffectonhostimmunity
AT liebermanlindaa il2defectinsystemiclupuserythematosusdiseasehasanexpansiveeffectonhostimmunity
AT tsokosgeorgec il2defectinsystemiclupuserythematosusdiseasehasanexpansiveeffectonhostimmunity

Ejemplares similares