Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

BACKGROUND: Selective neutralization of the IL21/IL21R signaling pathway is a promising approach for the treatment of a variety of autoimmune diseases. Ab-01 is a human neutralizing anti-IL21R antibody. In order to ensure that the activities of Ab-01 are restricted to neutralization even under in vi...

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Detalles Bibliográficos
Autores principales: Guo, Yongjing, Hill, Andrew A, Ramsey, Renee C, Immermann, Frederick W, Corcoran, Christopher, Young, Deborah, LaVallie, Edward R, Ryan, Mark, Bechard, Theresa, Pfeifer, Richard, Warner, Garvin, Bologna, Marcia, Bloom, Laird, O'Toole, Margot
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896924/
https://www.ncbi.nlm.nih.gov/pubmed/20504348
http://dx.doi.org/10.1186/1479-5876-8-50

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