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Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol
BACKGROUND: Cognitive dysfunction is common among depressed patients. However, the pattern and magnitude of impairment during episodes of major depressive disorder (MDD) through to clinical remission remains unclear. Heterogeneity of depressive patients and the lack of longitudinal studies may accou...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896936/ https://www.ncbi.nlm.nih.gov/pubmed/20565743 http://dx.doi.org/10.1186/1471-244X-10-48 |
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author | Monzón, Saray Gili, Margalida Vives, Margalida Serrano, Maria Jesus Bauza, Natalia Molina, Rosa García-Toro, Mauro Salvà, Joan Llobera, Joan Roca, Miquel |
author_facet | Monzón, Saray Gili, Margalida Vives, Margalida Serrano, Maria Jesus Bauza, Natalia Molina, Rosa García-Toro, Mauro Salvà, Joan Llobera, Joan Roca, Miquel |
author_sort | Monzón, Saray |
collection | PubMed |
description | BACKGROUND: Cognitive dysfunction is common among depressed patients. However, the pattern and magnitude of impairment during episodes of major depressive disorder (MDD) through to clinical remission remains unclear. Heterogeneity of depressive patients and the lack of longitudinal studies may account for contradictory results in previous research. METHODS/DESIGN: This longitudinal study will analyze cognitive differences between CORE-defined melancholic depressed patients (n = 60) and non-melancholic depressed patients (n = 60). A comprehensive clinical and cognitive assessment will be performed at admission and after 6 months. Cognitive dysfunction in both groups will be longitudinally compared, and the persistence of cognitive impairment after clinical remission will be determined. DISCUSSION: The study of neuropsychological dysfunction and the cognitive changes through the different phases of depression arise a wide variety of difficulties. Several confounding variables must be controlled to determine if the presence of depression could be considered the only factor accounting for group differences. |
format | Text |
id | pubmed-2896936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28969362010-07-06 Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol Monzón, Saray Gili, Margalida Vives, Margalida Serrano, Maria Jesus Bauza, Natalia Molina, Rosa García-Toro, Mauro Salvà, Joan Llobera, Joan Roca, Miquel BMC Psychiatry Study protocol BACKGROUND: Cognitive dysfunction is common among depressed patients. However, the pattern and magnitude of impairment during episodes of major depressive disorder (MDD) through to clinical remission remains unclear. Heterogeneity of depressive patients and the lack of longitudinal studies may account for contradictory results in previous research. METHODS/DESIGN: This longitudinal study will analyze cognitive differences between CORE-defined melancholic depressed patients (n = 60) and non-melancholic depressed patients (n = 60). A comprehensive clinical and cognitive assessment will be performed at admission and after 6 months. Cognitive dysfunction in both groups will be longitudinally compared, and the persistence of cognitive impairment after clinical remission will be determined. DISCUSSION: The study of neuropsychological dysfunction and the cognitive changes through the different phases of depression arise a wide variety of difficulties. Several confounding variables must be controlled to determine if the presence of depression could be considered the only factor accounting for group differences. BioMed Central 2010-06-17 /pmc/articles/PMC2896936/ /pubmed/20565743 http://dx.doi.org/10.1186/1471-244X-10-48 Text en Copyright ©2010 Monzón et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study protocol Monzón, Saray Gili, Margalida Vives, Margalida Serrano, Maria Jesus Bauza, Natalia Molina, Rosa García-Toro, Mauro Salvà, Joan Llobera, Joan Roca, Miquel Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol |
title | Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol |
title_full | Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol |
title_fullStr | Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol |
title_full_unstemmed | Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol |
title_short | Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol |
title_sort | melancholic versus non-melancholic depression: differences on cognitive function. a longitudinal study protocol |
topic | Study protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896936/ https://www.ncbi.nlm.nih.gov/pubmed/20565743 http://dx.doi.org/10.1186/1471-244X-10-48 |
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