Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT(2C )receptor-dependent pathways

BACKGROUND: Agomelatine is a melatonergic receptor agonist and a 5HT(2C )receptor antagonist that has shown antidepressant efficacy. In order to analyze separately the effect of the two receptorial components, rats were chronically treated with agomelatine, melatonin (endogenous melatonergic agonist...

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Detalles Bibliográficos
Autores principales: Tardito, Daniela, Milanese, Marco, Bonifacino, Tiziana, Musazzi, Laura, Grilli, Massimo, Mallei, Alessandra, Mocaer, Elisabeth, Gabriel-Gracia, Cecilia, Racagni, Giorgio, Popoli, Maurizio, Bonanno, Giambattista
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896952/
https://www.ncbi.nlm.nih.gov/pubmed/20525261
http://dx.doi.org/10.1186/1471-2202-11-68

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