Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

BACKGROUND: Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS: To...

Descripción completa

Detalles Bibliográficos
Autores principales: Méndez, Olga, Zavadil, Jiri, Esencay, Mine, Lukyanov, Yevgeniy, Santovasi, Daniel, Wang, Shu-Chi, Newcomb, Elizabeth W, Zagzag, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896954/
https://www.ncbi.nlm.nih.gov/pubmed/20515450
http://dx.doi.org/10.1186/1476-4598-9-133

Ejemplares similares

Ejemplares similares