Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis

The RNA-dependent RNA-polymerase, 3D(pol), is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3D(pol) in mice has antiviral effects. Here, we discuss the structure and function of 3D(pol) during picornavirus replication,...

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Detalles Bibliográficos
Autores principales: Kerkvliet, Jason, Edukulla, Ramakrishna, Rodriguez, Moses
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897181/
https://www.ncbi.nlm.nih.gov/pubmed/20625447
http://dx.doi.org/10.1155/2010/368068
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author Kerkvliet, Jason
Edukulla, Ramakrishna
Rodriguez, Moses
author_facet Kerkvliet, Jason
Edukulla, Ramakrishna
Rodriguez, Moses
author_sort Kerkvliet, Jason
collection PubMed
description The RNA-dependent RNA-polymerase, 3D(pol), is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3D(pol) in mice has antiviral effects. Here, we discuss the structure and function of 3D(pol) during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3D(pol) after picornavirus infection, highlight data showing the antiviral effects of transgenic 3D(pol) from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3D(pol) is causing this antiviral effect in mice.
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spelling pubmed-28971812011-01-01 Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis Kerkvliet, Jason Edukulla, Ramakrishna Rodriguez, Moses Adv Virol Review Article The RNA-dependent RNA-polymerase, 3D(pol), is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3D(pol) in mice has antiviral effects. Here, we discuss the structure and function of 3D(pol) during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3D(pol) after picornavirus infection, highlight data showing the antiviral effects of transgenic 3D(pol) from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3D(pol) is causing this antiviral effect in mice. Hindawi Publishing Corporation 2010 2010-06-29 /pmc/articles/PMC2897181/ /pubmed/20625447 http://dx.doi.org/10.1155/2010/368068 Text en Copyright © 2010 Jason Kerkvliet et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kerkvliet, Jason
Edukulla, Ramakrishna
Rodriguez, Moses
Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
title Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
title_full Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
title_fullStr Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
title_full_unstemmed Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
title_short Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
title_sort novel roles of the picornaviral 3d polymerase in viral pathogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897181/
https://www.ncbi.nlm.nih.gov/pubmed/20625447
http://dx.doi.org/10.1155/2010/368068
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AT edukullaramakrishna novelrolesofthepicornaviral3dpolymeraseinviralpathogenesis
AT rodriguezmoses novelrolesofthepicornaviral3dpolymeraseinviralpathogenesis

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