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Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex
Cerebral cortex is comprised of regions including six-layer neocortex and three-layer olfactory cortex generated by telencephalic progenitors of an Emx1 lineage. The mechanism specifying region-specific subpopulations within this lineage is unknown. We show in mouse that the LIM homeodomain transcri...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897740/ https://www.ncbi.nlm.nih.gov/pubmed/19820705 http://dx.doi.org/10.1038/nn.2427 |
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author | Chou, Shen-Ju Perez-Garcia, Carlos G. Kroll, Todd T. O’Leary, Dennis D.M. |
author_facet | Chou, Shen-Ju Perez-Garcia, Carlos G. Kroll, Todd T. O’Leary, Dennis D.M. |
author_sort | Chou, Shen-Ju |
collection | PubMed |
description | Cerebral cortex is comprised of regions including six-layer neocortex and three-layer olfactory cortex generated by telencephalic progenitors of an Emx1 lineage. The mechanism specifying region-specific subpopulations within this lineage is unknown. We show in mouse that the LIM homeodomain transcription factor Lhx2, expressed in graded levels by progenitors, determines their regional identity and fate decisions to generate neocortex or olfactory cortex. Emx1-Cre deletion of Lhx2 at E10.5 refates progenitors to generate three-layer cortex phenocopying olfactory cortex rather than lateral neocortex. Progenitors do not generate ectopic olfactory cortex following Lhx2 deletion at E11.5. Thus, Lhx2 regulates a regional-fate decision by telencephalic progenitors during a critical period that closes as they differentiate from neuroepithelial cells to neuronogenic radial glia. “Exposure” of progenitors to Lhx2 may dictate their regional-fate decisions. These findings establish a genetic mechanism determining regional fate in the Emx1 lineage of telencephalic progenitors that generate cerebral cortex. |
format | Text |
id | pubmed-2897740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-28977402010-07-06 Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex Chou, Shen-Ju Perez-Garcia, Carlos G. Kroll, Todd T. O’Leary, Dennis D.M. Nat Neurosci Article Cerebral cortex is comprised of regions including six-layer neocortex and three-layer olfactory cortex generated by telencephalic progenitors of an Emx1 lineage. The mechanism specifying region-specific subpopulations within this lineage is unknown. We show in mouse that the LIM homeodomain transcription factor Lhx2, expressed in graded levels by progenitors, determines their regional identity and fate decisions to generate neocortex or olfactory cortex. Emx1-Cre deletion of Lhx2 at E10.5 refates progenitors to generate three-layer cortex phenocopying olfactory cortex rather than lateral neocortex. Progenitors do not generate ectopic olfactory cortex following Lhx2 deletion at E11.5. Thus, Lhx2 regulates a regional-fate decision by telencephalic progenitors during a critical period that closes as they differentiate from neuroepithelial cells to neuronogenic radial glia. “Exposure” of progenitors to Lhx2 may dictate their regional-fate decisions. These findings establish a genetic mechanism determining regional fate in the Emx1 lineage of telencephalic progenitors that generate cerebral cortex. 2009-10-11 2009-11 /pmc/articles/PMC2897740/ /pubmed/19820705 http://dx.doi.org/10.1038/nn.2427 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Chou, Shen-Ju Perez-Garcia, Carlos G. Kroll, Todd T. O’Leary, Dennis D.M. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex |
title | Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex |
title_full | Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex |
title_fullStr | Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex |
title_full_unstemmed | Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex |
title_short | Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex |
title_sort | lhx2 specifies regional fate in emx1 lineage of telencephalic progenitors generating cerebral cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897740/ https://www.ncbi.nlm.nih.gov/pubmed/19820705 http://dx.doi.org/10.1038/nn.2427 |
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