Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition

The actin capping protein (CP) tightly binds to the barbed end of actin filaments, thus playing a key role in actin-based lamellipodial dynamics. V-1 and CARMIL proteins directly bind to CP and inhibit the filament capping activity of CP. V-1 completely inhibits CP from interacting with the barbed e...

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Detalles Bibliográficos
Autores principales: Takeda, Shuichi, Minakata, Shiho, Koike, Ryotaro, Kawahata, Ichiro, Narita, Akihiro, Kitazawa, Masashi, Ota, Motonori, Yamakuni, Tohru, Maéda, Yuichiro, Nitanai, Yasushi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897767/
https://www.ncbi.nlm.nih.gov/pubmed/20625546
http://dx.doi.org/10.1371/journal.pbio.1000416

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