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Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity

BACKGROUND: Imbalance of iron homeostasis has been reported in sporadic Creutzfeldt-Jakob-disease (sCJD) affected human and scrapie infected animal brains, but the contribution of this phenotype to disease associated neurotoxicity is unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using cell models of fami...

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Detalles Bibliográficos
Autores principales:	Das, Dola, Luo, Xiu, Singh, Ajay, Gu, Yaping, Ghosh, Soumya, Mukhopadhyay, Chinmay K., Chen, Shu G., Sy, Man-Sun, Kong, Qingzhong, Singh, Neena
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897850/ https://www.ncbi.nlm.nih.gov/pubmed/20625431 http://dx.doi.org/10.1371/journal.pone.0011420

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