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Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City
The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898023/ https://www.ncbi.nlm.nih.gov/pubmed/20622999 http://dx.doi.org/10.3390/ijerph7051889 |
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author | Jung, Kyung Hwa Yan, Beizhan Chillrud, Steven N. Perera, Frederica P. Whyatt, Robin Camann, David Kinney, Patrick L. Miller, Rachel L. |
author_facet | Jung, Kyung Hwa Yan, Beizhan Chillrud, Steven N. Perera, Frederica P. Whyatt, Robin Camann, David Kinney, Patrick L. Miller, Rachel L. |
author_sort | Jung, Kyung Hwa |
collection | PubMed |
description | The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5–6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (Σ(8)PAH; MW ≥ 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ)(Σ8PAH) and (BaP-MEQ)(Σ8PAH) both indoors and outdoors (p < 0.001). Outdoor (BaP-TEQ)(Σ8)(PAH) and (BaP-MEQ)(Σ8PAH) were significantly higher than the corresponding indoor measures during the heating season (p < 0.01). These findings suggest that at levels encountered in New York City air, especially during the heating season, residential exposure to PAH may pose an increased risk of cancer and mutation. |
format | Text |
id | pubmed-2898023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-28980232010-07-09 Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City Jung, Kyung Hwa Yan, Beizhan Chillrud, Steven N. Perera, Frederica P. Whyatt, Robin Camann, David Kinney, Patrick L. Miller, Rachel L. Int J Environ Res Public Health Article The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5–6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (Σ(8)PAH; MW ≥ 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ)(Σ8PAH) and (BaP-MEQ)(Σ8PAH) both indoors and outdoors (p < 0.001). Outdoor (BaP-TEQ)(Σ8)(PAH) and (BaP-MEQ)(Σ8PAH) were significantly higher than the corresponding indoor measures during the heating season (p < 0.01). These findings suggest that at levels encountered in New York City air, especially during the heating season, residential exposure to PAH may pose an increased risk of cancer and mutation. Molecular Diversity Preservation International (MDPI) 2010-05 2010-04-27 /pmc/articles/PMC2898023/ /pubmed/20622999 http://dx.doi.org/10.3390/ijerph7051889 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Jung, Kyung Hwa Yan, Beizhan Chillrud, Steven N. Perera, Frederica P. Whyatt, Robin Camann, David Kinney, Patrick L. Miller, Rachel L. Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City |
title | Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City |
title_full | Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City |
title_fullStr | Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City |
title_full_unstemmed | Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City |
title_short | Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City |
title_sort | assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in new york city |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898023/ https://www.ncbi.nlm.nih.gov/pubmed/20622999 http://dx.doi.org/10.3390/ijerph7051889 |
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