Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling

The development of bispecific antibodies as therapeutic agents for human diseases has great clinical potential, but broad application has been hindered by the difficulty of identifying bispecific antibody formats that exhibit favorable pharmacokinetic properties and ease of large-scale manufacturing...

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Detalles Bibliográficos
Autores principales: Jackman, Janet, Chen, Yongmei, Huang, Arthur, Moffat, Barbara, Scheer, Justin M., Leong, Steven R., Lee, Wyne P., Zhang, Juan, Sharma, Navneet, Lu, Yanmei, Iyer, Suhasini, Shields, Robert L., Chiang, Nancy, Bauer, Michele C., Wadley, Diana, Roose-Girma, Merone, Vandlen, Richard, Yansura, Daniel G., Wu, Yan, Wu, Lawren C.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898330/
https://www.ncbi.nlm.nih.gov/pubmed/20444694
http://dx.doi.org/10.1074/jbc.M110.113910

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