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The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia
BACKGROUND: Atypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics; nevertheless, their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898740/ https://www.ncbi.nlm.nih.gov/pubmed/20550658 http://dx.doi.org/10.1186/1471-244X-10-47 |
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author | Selva-Vera, Gabriel Balanzá-Martínez, Vicent Salazar-Fraile, José Sánchez-Moreno, José Martinez-Aran, Anabel Correa, Patricia Vieta, Eduard Tabarés-Seisdedos, Rafael |
author_facet | Selva-Vera, Gabriel Balanzá-Martínez, Vicent Salazar-Fraile, José Sánchez-Moreno, José Martinez-Aran, Anabel Correa, Patricia Vieta, Eduard Tabarés-Seisdedos, Rafael |
author_sort | Selva-Vera, Gabriel |
collection | PubMed |
description | BACKGROUND: Atypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics; nevertheless, their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes in cognition associated with long-term antipsychotic treatment and to evaluate the effect of the type of antipsychotic (conventional versus novel antipsychotic drugs) on cognitive performance over time. METHODS: In this naturalistic study, we used a comprehensive neuropsychological battery of tests to assess a sample of schizophrenia patients taking either conventional (n = 13) or novel antipsychotics (n = 26) at baseline and at two years after. RESULTS: Continuous antipsychotic treatment regardless of class was associated with improvement on verbal fluency, executive functions, and visual and verbal memory. Patients taking atypical antipsychotics did not show greater cognitive enhancement over two years than patients taking conventional antipsychotics. CONCLUSIONS: Although long-term antipsychotic treatment slightly improved cognitive function, the switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of these cognitive deficits. |
format | Text |
id | pubmed-2898740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28987402010-07-08 The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia Selva-Vera, Gabriel Balanzá-Martínez, Vicent Salazar-Fraile, José Sánchez-Moreno, José Martinez-Aran, Anabel Correa, Patricia Vieta, Eduard Tabarés-Seisdedos, Rafael BMC Psychiatry Research article BACKGROUND: Atypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics; nevertheless, their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes in cognition associated with long-term antipsychotic treatment and to evaluate the effect of the type of antipsychotic (conventional versus novel antipsychotic drugs) on cognitive performance over time. METHODS: In this naturalistic study, we used a comprehensive neuropsychological battery of tests to assess a sample of schizophrenia patients taking either conventional (n = 13) or novel antipsychotics (n = 26) at baseline and at two years after. RESULTS: Continuous antipsychotic treatment regardless of class was associated with improvement on verbal fluency, executive functions, and visual and verbal memory. Patients taking atypical antipsychotics did not show greater cognitive enhancement over two years than patients taking conventional antipsychotics. CONCLUSIONS: Although long-term antipsychotic treatment slightly improved cognitive function, the switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of these cognitive deficits. BioMed Central 2010-06-15 /pmc/articles/PMC2898740/ /pubmed/20550658 http://dx.doi.org/10.1186/1471-244X-10-47 Text en Copyright ©2010 Selva-Vera et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Selva-Vera, Gabriel Balanzá-Martínez, Vicent Salazar-Fraile, José Sánchez-Moreno, José Martinez-Aran, Anabel Correa, Patricia Vieta, Eduard Tabarés-Seisdedos, Rafael The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia |
title | The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia |
title_full | The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia |
title_fullStr | The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia |
title_full_unstemmed | The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia |
title_short | The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia |
title_sort | switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. a pilot study in individuals with schizophrenia |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898740/ https://www.ncbi.nlm.nih.gov/pubmed/20550658 http://dx.doi.org/10.1186/1471-244X-10-47 |
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