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Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles

BACKGROUND: Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quas...

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Autores principales: Delfino, Ralph J., Staimer, Norbert, Tjoa, Thomas, Arhami, Mohammad, Polidori, Andrea, Gillen, Daniel L., Kleinman, Michael T., Schauer, James J., Sioutas, Constantinos
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898850/
https://www.ncbi.nlm.nih.gov/pubmed/20123637
http://dx.doi.org/10.1289/ehp.0901407
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author Delfino, Ralph J.
Staimer, Norbert
Tjoa, Thomas
Arhami, Mohammad
Polidori, Andrea
Gillen, Daniel L.
Kleinman, Michael T.
Schauer, James J.
Sioutas, Constantinos
author_facet Delfino, Ralph J.
Staimer, Norbert
Tjoa, Thomas
Arhami, Mohammad
Polidori, Andrea
Gillen, Daniel L.
Kleinman, Michael T.
Schauer, James J.
Sioutas, Constantinos
author_sort Delfino, Ralph J.
collection PubMed
description BACKGROUND: Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles ≤ 0.25 μm in aerodynamic diameter (PM(0.25)) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin. OBJECTIVES: We reassessed biomarker associations with PM(0.25) using new particle composition data. METHODS: Weekly biomarkers of inflammation were plasma interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor II (sTNF-RII) (n = 578). Exposures included indoor and outdoor community organic PM(0.25) constituents [polycyclic aromatic hydrocarbons (PAHs), hopanes, n-alkanes, organic acids, water-soluble organic carbon, and transition metals]. We analyzed the relation between biomarkers and exposures with mixed-effects models adjusted for potential confounders. RESULTS: Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed by hopanes (vehicle emissions tracer), were positively associated with biomarkers, but other organic components and transition metals were not. sTNF-RII increased by 135 pg/mL [95% confidence interval (CI), 45–225 pg/mL], and IL-6 increased by 0.27 pg/mL (95% CI, 0.10–0.44 pg/mL) per interquartile range increase of 0.56 ng/m(3) outdoor total PAHs. Two-pollutant models of PM(0.25) with PAHs showed that nominal associations of IL-6 and sTNF-RII with PM(0.25) mass were completely confounded by PAHs. Vehicular emission sources estimated from chemical mass balance models were strongly correlated with PAHs (R = 0.71). CONCLUSIONS: Traffic emission sources of organic chemicals represented by PAHs are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass.
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spelling pubmed-28988502010-07-23 Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles Delfino, Ralph J. Staimer, Norbert Tjoa, Thomas Arhami, Mohammad Polidori, Andrea Gillen, Daniel L. Kleinman, Michael T. Schauer, James J. Sioutas, Constantinos Environ Health Perspect Research BACKGROUND: Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles ≤ 0.25 μm in aerodynamic diameter (PM(0.25)) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin. OBJECTIVES: We reassessed biomarker associations with PM(0.25) using new particle composition data. METHODS: Weekly biomarkers of inflammation were plasma interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor II (sTNF-RII) (n = 578). Exposures included indoor and outdoor community organic PM(0.25) constituents [polycyclic aromatic hydrocarbons (PAHs), hopanes, n-alkanes, organic acids, water-soluble organic carbon, and transition metals]. We analyzed the relation between biomarkers and exposures with mixed-effects models adjusted for potential confounders. RESULTS: Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed by hopanes (vehicle emissions tracer), were positively associated with biomarkers, but other organic components and transition metals were not. sTNF-RII increased by 135 pg/mL [95% confidence interval (CI), 45–225 pg/mL], and IL-6 increased by 0.27 pg/mL (95% CI, 0.10–0.44 pg/mL) per interquartile range increase of 0.56 ng/m(3) outdoor total PAHs. Two-pollutant models of PM(0.25) with PAHs showed that nominal associations of IL-6 and sTNF-RII with PM(0.25) mass were completely confounded by PAHs. Vehicular emission sources estimated from chemical mass balance models were strongly correlated with PAHs (R = 0.71). CONCLUSIONS: Traffic emission sources of organic chemicals represented by PAHs are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass. National Institute of Environmental Health Sciences 2010-06 2010-02-02 /pmc/articles/PMC2898850/ /pubmed/20123637 http://dx.doi.org/10.1289/ehp.0901407 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Delfino, Ralph J.
Staimer, Norbert
Tjoa, Thomas
Arhami, Mohammad
Polidori, Andrea
Gillen, Daniel L.
Kleinman, Michael T.
Schauer, James J.
Sioutas, Constantinos
Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles
title Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles
title_full Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles
title_fullStr Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles
title_full_unstemmed Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles
title_short Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles
title_sort association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898850/
https://www.ncbi.nlm.nih.gov/pubmed/20123637
http://dx.doi.org/10.1289/ehp.0901407
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