Cargando…

Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study

BACKGROUND: Melanoma rates continue to increase; however, few risk factors other than sun sensitivity and ultraviolet radiation (including sun exposure) have been identified. Although studies of farmers have shown an excess risk of melanoma and other skin cancers, it is unclear how much of this is r...

Descripción completa

Detalles Bibliográficos
Autores principales: Dennis, Leslie K., Lynch, Charles F., Sandler, Dale P., Alavanja, Michael C.R.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898858/
https://www.ncbi.nlm.nih.gov/pubmed/20164001
http://dx.doi.org/10.1289/ehp.0901518
_version_ 1782183534462500864
author Dennis, Leslie K.
Lynch, Charles F.
Sandler, Dale P.
Alavanja, Michael C.R.
author_facet Dennis, Leslie K.
Lynch, Charles F.
Sandler, Dale P.
Alavanja, Michael C.R.
author_sort Dennis, Leslie K.
collection PubMed
description BACKGROUND: Melanoma rates continue to increase; however, few risk factors other than sun sensitivity and ultraviolet radiation (including sun exposure) have been identified. Although studies of farmers have shown an excess risk of melanoma and other skin cancers, it is unclear how much of this is related to sun exposure compared with other agricultural exposures. METHODS: We examined dose–response relationships for 50 agricultural pesticides and cutaneous melanoma incidence in the Agricultural Health Study cohort of licensed pesticide applicators, along with ever use of older pesticides that contain arsenic. Logistic regression was used to examine odds ratios (ORs) and 95% confidence intervals (CIs) associated with pesticide exposure adjusted for age, sex, and other potential confounders. RESULTS: We found significant associations between cutaneous melanoma and maneb/mancozeb (63 exposure days: OR = 2.4; 95% CI, 1.2–4.9; trend p = 0.006), parathion (≥ 56 exposure days: OR = 2.4; 95% CI, 1.3–4.4; trend p = 0.003), and carbaryl (≥ 56 exposure days: OR = 1.7; 95% CI, 1.1–2.5; trend p = 0.013). Other associations with benomyl and ever use of arsenical pesticides were also suggested. CONCLUSIONS: Most previous melanoma literature has focused on host factors and sun exposure. Our research shows an association between several pesticides and melanoma, providing support for the hypotheses that agricultural chemicals may be another important source of melanoma risk.
format Text
id pubmed-2898858
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher National Institute of Environmental Health Sciences
record_format MEDLINE/PubMed
spelling pubmed-28988582010-07-23 Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study Dennis, Leslie K. Lynch, Charles F. Sandler, Dale P. Alavanja, Michael C.R. Environ Health Perspect Research BACKGROUND: Melanoma rates continue to increase; however, few risk factors other than sun sensitivity and ultraviolet radiation (including sun exposure) have been identified. Although studies of farmers have shown an excess risk of melanoma and other skin cancers, it is unclear how much of this is related to sun exposure compared with other agricultural exposures. METHODS: We examined dose–response relationships for 50 agricultural pesticides and cutaneous melanoma incidence in the Agricultural Health Study cohort of licensed pesticide applicators, along with ever use of older pesticides that contain arsenic. Logistic regression was used to examine odds ratios (ORs) and 95% confidence intervals (CIs) associated with pesticide exposure adjusted for age, sex, and other potential confounders. RESULTS: We found significant associations between cutaneous melanoma and maneb/mancozeb (63 exposure days: OR = 2.4; 95% CI, 1.2–4.9; trend p = 0.006), parathion (≥ 56 exposure days: OR = 2.4; 95% CI, 1.3–4.4; trend p = 0.003), and carbaryl (≥ 56 exposure days: OR = 1.7; 95% CI, 1.1–2.5; trend p = 0.013). Other associations with benomyl and ever use of arsenical pesticides were also suggested. CONCLUSIONS: Most previous melanoma literature has focused on host factors and sun exposure. Our research shows an association between several pesticides and melanoma, providing support for the hypotheses that agricultural chemicals may be another important source of melanoma risk. National Institute of Environmental Health Sciences 2010-06 2010-02-17 /pmc/articles/PMC2898858/ /pubmed/20164001 http://dx.doi.org/10.1289/ehp.0901518 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Dennis, Leslie K.
Lynch, Charles F.
Sandler, Dale P.
Alavanja, Michael C.R.
Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study
title Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study
title_full Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study
title_fullStr Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study
title_full_unstemmed Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study
title_short Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study
title_sort pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898858/
https://www.ncbi.nlm.nih.gov/pubmed/20164001
http://dx.doi.org/10.1289/ehp.0901518
work_keys_str_mv AT dennislesliek pesticideuseandcutaneousmelanomainpesticideapplicatorsintheagriculturalheathstudy
AT lynchcharlesf pesticideuseandcutaneousmelanomainpesticideapplicatorsintheagriculturalheathstudy
AT sandlerdalep pesticideuseandcutaneousmelanomainpesticideapplicatorsintheagriculturalheathstudy
AT alavanjamichaelcr pesticideuseandcutaneousmelanomainpesticideapplicatorsintheagriculturalheathstudy