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Revisiting the Role of Neurons in Neurovascular Coupling
In this article, we will review molecular, anatomical, physiological and pharmacological data in an attempt to better understand how excitatory and inhibitory neurons recruited by distinct afferent inputs to the cerebral cortex contribute to the coupled hemodynamic response, and how astrocytes can a...
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899521/ https://www.ncbi.nlm.nih.gov/pubmed/20616884 http://dx.doi.org/10.3389/fnene.2010.00009 |
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author | Cauli, Bruno Hamel, Edith |
author_facet | Cauli, Bruno Hamel, Edith |
author_sort | Cauli, Bruno |
collection | PubMed |
description | In this article, we will review molecular, anatomical, physiological and pharmacological data in an attempt to better understand how excitatory and inhibitory neurons recruited by distinct afferent inputs to the cerebral cortex contribute to the coupled hemodynamic response, and how astrocytes can act as intermediaries to these neuronal populations. We aim at providing the pros and cons to the following statements that, depending on the nature of the afferent input to the neocortex, (i) different neuronal or astroglial messengers, likely acting in sequence, mediate the hemodynamic changes, (ii) some recruited neurons release messengers that directly alter blood vessel tone, (iii) others act by modulating neuronal and astroglial activity, and (iv) astrocytes act as intermediaries for both excitatory and inhibitory neurotransmitters. We will stress that a given afferent signal activates a precise neuronal circuitry that determines the mediators of the hemodynamic response as well as the level of interaction with surrounding astrocytes. |
format | Text |
id | pubmed-2899521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28995212010-07-08 Revisiting the Role of Neurons in Neurovascular Coupling Cauli, Bruno Hamel, Edith Front Neuroenergetics Neuroscience In this article, we will review molecular, anatomical, physiological and pharmacological data in an attempt to better understand how excitatory and inhibitory neurons recruited by distinct afferent inputs to the cerebral cortex contribute to the coupled hemodynamic response, and how astrocytes can act as intermediaries to these neuronal populations. We aim at providing the pros and cons to the following statements that, depending on the nature of the afferent input to the neocortex, (i) different neuronal or astroglial messengers, likely acting in sequence, mediate the hemodynamic changes, (ii) some recruited neurons release messengers that directly alter blood vessel tone, (iii) others act by modulating neuronal and astroglial activity, and (iv) astrocytes act as intermediaries for both excitatory and inhibitory neurotransmitters. We will stress that a given afferent signal activates a precise neuronal circuitry that determines the mediators of the hemodynamic response as well as the level of interaction with surrounding astrocytes. Frontiers Research Foundation 2010-06-23 /pmc/articles/PMC2899521/ /pubmed/20616884 http://dx.doi.org/10.3389/fnene.2010.00009 Text en Copyright © 2010 Cauli and Hamel. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Cauli, Bruno Hamel, Edith Revisiting the Role of Neurons in Neurovascular Coupling |
title | Revisiting the Role of Neurons in Neurovascular Coupling |
title_full | Revisiting the Role of Neurons in Neurovascular Coupling |
title_fullStr | Revisiting the Role of Neurons in Neurovascular Coupling |
title_full_unstemmed | Revisiting the Role of Neurons in Neurovascular Coupling |
title_short | Revisiting the Role of Neurons in Neurovascular Coupling |
title_sort | revisiting the role of neurons in neurovascular coupling |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899521/ https://www.ncbi.nlm.nih.gov/pubmed/20616884 http://dx.doi.org/10.3389/fnene.2010.00009 |
work_keys_str_mv | AT caulibruno revisitingtheroleofneuronsinneurovascularcoupling AT hameledith revisitingtheroleofneuronsinneurovascularcoupling |