Interplay between Cdh1 and JNK activity during the cell cycle

The ubiquitin ligase APC/C(Cdh1) coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and G1 phase of the cell cycle. Expression of a non-degradable JNK induces...

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Autores principales: Gutierrez, Gustavo J., Tsuji, Toshiya, Chen, Meifan, Jiang, Wei, Ronai, Ze’ev A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899685/
https://www.ncbi.nlm.nih.gov/pubmed/20581839
http://dx.doi.org/10.1038/ncb2071
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author Gutierrez, Gustavo J.
Tsuji, Toshiya
Chen, Meifan
Jiang, Wei
Ronai, Ze’ev A.
author_facet Gutierrez, Gustavo J.
Tsuji, Toshiya
Chen, Meifan
Jiang, Wei
Ronai, Ze’ev A.
author_sort Gutierrez, Gustavo J.
collection PubMed
description The ubiquitin ligase APC/C(Cdh1) coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK directly phosphorylates Cdh1, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. The newly identified regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.
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spelling pubmed-28996852011-01-01 Interplay between Cdh1 and JNK activity during the cell cycle Gutierrez, Gustavo J. Tsuji, Toshiya Chen, Meifan Jiang, Wei Ronai, Ze’ev A. Nat Cell Biol Article The ubiquitin ligase APC/C(Cdh1) coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK directly phosphorylates Cdh1, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. The newly identified regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle. 2010-06-27 2010-07 /pmc/articles/PMC2899685/ /pubmed/20581839 http://dx.doi.org/10.1038/ncb2071 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gutierrez, Gustavo J.
Tsuji, Toshiya
Chen, Meifan
Jiang, Wei
Ronai, Ze’ev A.
Interplay between Cdh1 and JNK activity during the cell cycle
title Interplay between Cdh1 and JNK activity during the cell cycle
title_full Interplay between Cdh1 and JNK activity during the cell cycle
title_fullStr Interplay between Cdh1 and JNK activity during the cell cycle
title_full_unstemmed Interplay between Cdh1 and JNK activity during the cell cycle
title_short Interplay between Cdh1 and JNK activity during the cell cycle
title_sort interplay between cdh1 and jnk activity during the cell cycle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899685/
https://www.ncbi.nlm.nih.gov/pubmed/20581839
http://dx.doi.org/10.1038/ncb2071
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AT chenmeifan interplaybetweencdh1andjnkactivityduringthecellcycle
AT jiangwei interplaybetweencdh1andjnkactivityduringthecellcycle
AT ronaizeeva interplaybetweencdh1andjnkactivityduringthecellcycle

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