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Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout
INTRODUCTION: Gout is a common and disabling cause of arthritis in middle-aged and elderly populations, with its main predisposing factor being hyperuricemia (serum urate > 6.8 mg/dL). Options for treatment of chronic gout until 2008 were allopurinol, a xanthine oxidase inhibitor, and the group o...
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899777/ https://www.ncbi.nlm.nih.gov/pubmed/20694062 |
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author | Gaffo, Angelo L Saag, Kenneth G |
author_facet | Gaffo, Angelo L Saag, Kenneth G |
author_sort | Gaffo, Angelo L |
collection | PubMed |
description | INTRODUCTION: Gout is a common and disabling cause of arthritis in middle-aged and elderly populations, with its main predisposing factor being hyperuricemia (serum urate > 6.8 mg/dL). Options for treatment of chronic gout until 2008 were allopurinol, a xanthine oxidase inhibitor, and the group of drugs known as uricosurics that stimulate the renal excretion of uric acid. A proportion of patients, including some with chronic kidney disease and solid organ transplantations, could not be treated with the those therapies because of intolerance, drug interactions, or adverse events. Febuxostat is a nonpurine xanthine oxidase inhibitor, recently approved in Europe and the United States for the treatment of chronic gout. AIM: To review the clinical evidence (phase II and III studies) of the effectiveness and safety of febuxostat for treatment of hyperuricemia and gout. EVIDENCE REVIEW: Febuxostat, at doses ranging from 40 to 240 mg/day, is efficacious in reducing serum urate in patients with hyperuricemia and gout, comparing favorably with fixed doses of allopurinol in that respect. Early safety signals with respect to liver test abnormalities and cardiovascular outcomes have not been confirmed in recent large prospective trials but need to be further monitored. CLINICAL POTENTIAL: Given its low cost and extensive clinical experience, allopurinol will likely remain the first-line drug for management of hyperuricemia and gout. Febuxostat may provide an important option in patients unable to use allopurinol, those with very high serum urate levels, or in the presence of refractory tophi. |
format | Text |
id | pubmed-2899777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28997772010-08-05 Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout Gaffo, Angelo L Saag, Kenneth G Core Evid Review INTRODUCTION: Gout is a common and disabling cause of arthritis in middle-aged and elderly populations, with its main predisposing factor being hyperuricemia (serum urate > 6.8 mg/dL). Options for treatment of chronic gout until 2008 were allopurinol, a xanthine oxidase inhibitor, and the group of drugs known as uricosurics that stimulate the renal excretion of uric acid. A proportion of patients, including some with chronic kidney disease and solid organ transplantations, could not be treated with the those therapies because of intolerance, drug interactions, or adverse events. Febuxostat is a nonpurine xanthine oxidase inhibitor, recently approved in Europe and the United States for the treatment of chronic gout. AIM: To review the clinical evidence (phase II and III studies) of the effectiveness and safety of febuxostat for treatment of hyperuricemia and gout. EVIDENCE REVIEW: Febuxostat, at doses ranging from 40 to 240 mg/day, is efficacious in reducing serum urate in patients with hyperuricemia and gout, comparing favorably with fixed doses of allopurinol in that respect. Early safety signals with respect to liver test abnormalities and cardiovascular outcomes have not been confirmed in recent large prospective trials but need to be further monitored. CLINICAL POTENTIAL: Given its low cost and extensive clinical experience, allopurinol will likely remain the first-line drug for management of hyperuricemia and gout. Febuxostat may provide an important option in patients unable to use allopurinol, those with very high serum urate levels, or in the presence of refractory tophi. Dove Medical Press 2010-06-15 2009 /pmc/articles/PMC2899777/ /pubmed/20694062 Text en © 2009 Gaffo and Saag, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Gaffo, Angelo L Saag, Kenneth G Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
title | Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
title_full | Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
title_fullStr | Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
title_full_unstemmed | Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
title_short | Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
title_sort | febuxostat: the evidence for its use in the treatment of hyperuricemia and gout |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899777/ https://www.ncbi.nlm.nih.gov/pubmed/20694062 |
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