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Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology
Alcohol dependence is a major problem in India. The pharmacological armamentarium for relapse prevention of alcohol has widened with the addition of new drugs. In this article, we review the pharmacology and efficacy of the four most important such drugs: disulfiram, naltrexone, acamprosate and topi...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899994/ https://www.ncbi.nlm.nih.gov/pubmed/20640061 http://dx.doi.org/10.4103/0019-5545.31514 |
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author | Grover, Sandeep Bhateja, Gaurav Basu, Debasish |
author_facet | Grover, Sandeep Bhateja, Gaurav Basu, Debasish |
author_sort | Grover, Sandeep |
collection | PubMed |
description | Alcohol dependence is a major problem in India. The pharmacological armamentarium for relapse prevention of alcohol has widened with the addition of new drugs. In this article, we review the pharmacology and efficacy of the four most important such drugs: disulfiram, naltrexone, acamprosate and topiramate. The first part of this two-part review series concerns the comparative pharmacology and the second part concerns the efficacy studies. Overall, all four of these drugs have modest but clinically significant usefulness as pharmacoprophylactic agents for relapse prevention or minimization of alcohol dependence. Combinations might be helpful, especially for naltrexone and acamprosate. The issue of supervision and compliance remains important, especially for such drugs as disulfiram and naltrexone. Topiramate is a promising new agent and requires further study. Disulfiram, while very effective in compliant patients, presents challenges in terms of patient selection and side effects. For patients with hepatic impairment, acamprosate is a good choice. |
format | Text |
id | pubmed-2899994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28999942010-07-16 Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology Grover, Sandeep Bhateja, Gaurav Basu, Debasish Indian J Psychiatry Review Article Alcohol dependence is a major problem in India. The pharmacological armamentarium for relapse prevention of alcohol has widened with the addition of new drugs. In this article, we review the pharmacology and efficacy of the four most important such drugs: disulfiram, naltrexone, acamprosate and topiramate. The first part of this two-part review series concerns the comparative pharmacology and the second part concerns the efficacy studies. Overall, all four of these drugs have modest but clinically significant usefulness as pharmacoprophylactic agents for relapse prevention or minimization of alcohol dependence. Combinations might be helpful, especially for naltrexone and acamprosate. The issue of supervision and compliance remains important, especially for such drugs as disulfiram and naltrexone. Topiramate is a promising new agent and requires further study. Disulfiram, while very effective in compliant patients, presents challenges in terms of patient selection and side effects. For patients with hepatic impairment, acamprosate is a good choice. Medknow Publications 2007 /pmc/articles/PMC2899994/ /pubmed/20640061 http://dx.doi.org/10.4103/0019-5545.31514 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Grover, Sandeep Bhateja, Gaurav Basu, Debasish Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology |
title | Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology |
title_full | Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology |
title_fullStr | Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology |
title_full_unstemmed | Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology |
title_short | Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology |
title_sort | pharmacoprophylaxis of alcohol dependence: review and update part i: pharmacology |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899994/ https://www.ncbi.nlm.nih.gov/pubmed/20640061 http://dx.doi.org/10.4103/0019-5545.31514 |
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