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Protective effects of quercetin on liver injury induced by ethanol

Quercetin, a natural compound of multiple origins, has broad biopharmacological effects, such as antioxidant, directly scavenging free radical, and hepatoprotectivity effects. This study is designed to investigate the interveneous effect of quercetin on liver injury induced by ethanol in rats. The r...

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Detalles Bibliográficos
Autor principal: Chen, Xi
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900062/
https://www.ncbi.nlm.nih.gov/pubmed/20668581
http://dx.doi.org/10.4103/0973-1296.62900
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author Chen, Xi
author_facet Chen, Xi
author_sort Chen, Xi
collection PubMed
description Quercetin, a natural compound of multiple origins, has broad biopharmacological effects, such as antioxidant, directly scavenging free radical, and hepatoprotectivity effects. This study is designed to investigate the interveneous effect of quercetin on liver injury induced by ethanol in rats. The rats that were orally treated with 50% ethanol for continuous ten days, which resulted in cell necrosis, fibrosis and inflammatory infiltration, were included in this study. Higher contents of AST, ALT ADH, γ-GT, TG in plasma and MDA in liver tissue, and lower content of GSH in liver tissue were highlighted in ethanol-treated rats when compared with healthy ones. The levels of cytokines such as IL-1β, IL-1, IL-6, IL-8, and TNF-α in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment. By preventive and synchronism treatment with quercetin for fourteen days, the contents of AST, ALT ADH, γ-GT, TG and MDA, and levels of IL-1β, IL-1, IL-6, IL-8, and TNF-α were significantly reduced, whereas GSH and level of IL-10 were obviously increased. It may be deduced that quercetin, by multiple mechanisms interplay, demonstrated somewhat protective effect on liver injury induced by ethanol in rats.
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spelling pubmed-29000622010-07-28 Protective effects of quercetin on liver injury induced by ethanol Chen, Xi Pharmacogn Mag Original Article Quercetin, a natural compound of multiple origins, has broad biopharmacological effects, such as antioxidant, directly scavenging free radical, and hepatoprotectivity effects. This study is designed to investigate the interveneous effect of quercetin on liver injury induced by ethanol in rats. The rats that were orally treated with 50% ethanol for continuous ten days, which resulted in cell necrosis, fibrosis and inflammatory infiltration, were included in this study. Higher contents of AST, ALT ADH, γ-GT, TG in plasma and MDA in liver tissue, and lower content of GSH in liver tissue were highlighted in ethanol-treated rats when compared with healthy ones. The levels of cytokines such as IL-1β, IL-1, IL-6, IL-8, and TNF-α in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment. By preventive and synchronism treatment with quercetin for fourteen days, the contents of AST, ALT ADH, γ-GT, TG and MDA, and levels of IL-1β, IL-1, IL-6, IL-8, and TNF-α were significantly reduced, whereas GSH and level of IL-10 were obviously increased. It may be deduced that quercetin, by multiple mechanisms interplay, demonstrated somewhat protective effect on liver injury induced by ethanol in rats. Medknow Publications 2010-04 2010-05-05 /pmc/articles/PMC2900062/ /pubmed/20668581 http://dx.doi.org/10.4103/0973-1296.62900 Text en © Pharmacognosy Magazine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chen, Xi
Protective effects of quercetin on liver injury induced by ethanol
title Protective effects of quercetin on liver injury induced by ethanol
title_full Protective effects of quercetin on liver injury induced by ethanol
title_fullStr Protective effects of quercetin on liver injury induced by ethanol
title_full_unstemmed Protective effects of quercetin on liver injury induced by ethanol
title_short Protective effects of quercetin on liver injury induced by ethanol
title_sort protective effects of quercetin on liver injury induced by ethanol
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900062/
https://www.ncbi.nlm.nih.gov/pubmed/20668581
http://dx.doi.org/10.4103/0973-1296.62900
work_keys_str_mv AT chenxi protectiveeffectsofquercetinonliverinjuryinducedbyethanol