Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark

The present study evaluated the anticholinesterase activity of cold and hot aqueous extracts of Ficus racemosa stem bark against rat brain acetylcholinesterase in vitro. Both the cold aqueous extract (FRC) and the hot aqueous extract (FRH) exhibited a dose dependent inhibition of rat brain acetylcho...

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Detalles Bibliográficos
Autores principales: Ahmed, Faiyaz, Urooj, Asna
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900063/
https://www.ncbi.nlm.nih.gov/pubmed/20668582
http://dx.doi.org/10.4103/0973-1296.62897
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author Ahmed, Faiyaz
Urooj, Asna
author_facet Ahmed, Faiyaz
Urooj, Asna
author_sort Ahmed, Faiyaz
collection PubMed
description The present study evaluated the anticholinesterase activity of cold and hot aqueous extracts of Ficus racemosa stem bark against rat brain acetylcholinesterase in vitro. Both the cold aqueous extract (FRC) and the hot aqueous extract (FRH) exhibited a dose dependent inhibition of rat brain acetylcholinesterase. FRH showed significantly higher (P ≤ 0.001) cholinesterase inhibitory activity compared to FRC; however, both the extracts did not show 50% inhibition of AChE at the doses tested (200-1000 μg ml(−1)). The IC(50) values of 1813 and 1331 μg ml(−1) were deduced for FRC and FRH, respectively (calculated by extrapolation using Boltzmann's dose response analysis).
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spelling pubmed-29000632010-07-28 Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark Ahmed, Faiyaz Urooj, Asna Pharmacogn Mag Original Article The present study evaluated the anticholinesterase activity of cold and hot aqueous extracts of Ficus racemosa stem bark against rat brain acetylcholinesterase in vitro. Both the cold aqueous extract (FRC) and the hot aqueous extract (FRH) exhibited a dose dependent inhibition of rat brain acetylcholinesterase. FRH showed significantly higher (P ≤ 0.001) cholinesterase inhibitory activity compared to FRC; however, both the extracts did not show 50% inhibition of AChE at the doses tested (200-1000 μg ml(−1)). The IC(50) values of 1813 and 1331 μg ml(−1) were deduced for FRC and FRH, respectively (calculated by extrapolation using Boltzmann's dose response analysis). Medknow Publications 2010-04 2010-05-05 /pmc/articles/PMC2900063/ /pubmed/20668582 http://dx.doi.org/10.4103/0973-1296.62897 Text en © Pharmacognosy Magazine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ahmed, Faiyaz
Urooj, Asna
Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
title Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
title_full Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
title_fullStr Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
title_full_unstemmed Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
title_short Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark
title_sort anticholinesterase activities of cold and hot aqueous extracts of f. racemosa stem bark
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900063/
https://www.ncbi.nlm.nih.gov/pubmed/20668582
http://dx.doi.org/10.4103/0973-1296.62897
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AT uroojasna anticholinesteraseactivitiesofcoldandhotaqueousextractsoffracemosastembark

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