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Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn

In this work, the chemical constituents, antibacterial and modulatory activities of the essential oil of Lantana camara Linn were studied. The essential oil was extracted from the leaves of L. camara by hydrodistillation method using Clevenger's apparatus and its chemical constituents were sepa...

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Autores principales: Sousa, Erlânio O., Silva, Natálya F., Rodrigues, Fabiola F. G., Campos, Adriana R., Lima, Sidney G., Costa, José Galberto M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900066/
https://www.ncbi.nlm.nih.gov/pubmed/20668570
http://dx.doi.org/10.4103/0973-1296.62890
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author Sousa, Erlânio O.
Silva, Natálya F.
Rodrigues, Fabiola F. G.
Campos, Adriana R.
Lima, Sidney G.
Costa, José Galberto M.
author_facet Sousa, Erlânio O.
Silva, Natálya F.
Rodrigues, Fabiola F. G.
Campos, Adriana R.
Lima, Sidney G.
Costa, José Galberto M.
author_sort Sousa, Erlânio O.
collection PubMed
description In this work, the chemical constituents, antibacterial and modulatory activities of the essential oil of Lantana camara Linn were studied. The essential oil was extracted from the leaves of L. camara by hydrodistillation method using Clevenger's apparatus and its chemical constituents were separated and identified by GC-MS, and the relative content of each constituent was determined by area normalization. Among the 25 identified components, bicyclogermacrene (19.42%), isocaryophyllene (16.70%), valecene (12.94%) and germacrene D (12.34%) were the main constituents. The oil was examined to antibacterial and modulatory activities against the multiresistant strains of Escherichia coli and Staphylococcus aureus by microdilution test. The results show an inhibitory activity to E. coli (MIC 512 μg/ml) and S. aureus (MIC 256 μg/ml). The synergism of the essential oil and aminoglycosides was verified too, with significant reduction of MICs (7 ×, 1250-5 μg/ml) against E. coli. It is suggested that the essential oil of Lantana camara Linn could be used as a source of plant-derived natural products with resistance-modifying activity.
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spelling pubmed-29000662010-07-28 Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn Sousa, Erlânio O. Silva, Natálya F. Rodrigues, Fabiola F. G. Campos, Adriana R. Lima, Sidney G. Costa, José Galberto M. Pharmacogn Mag Original Article In this work, the chemical constituents, antibacterial and modulatory activities of the essential oil of Lantana camara Linn were studied. The essential oil was extracted from the leaves of L. camara by hydrodistillation method using Clevenger's apparatus and its chemical constituents were separated and identified by GC-MS, and the relative content of each constituent was determined by area normalization. Among the 25 identified components, bicyclogermacrene (19.42%), isocaryophyllene (16.70%), valecene (12.94%) and germacrene D (12.34%) were the main constituents. The oil was examined to antibacterial and modulatory activities against the multiresistant strains of Escherichia coli and Staphylococcus aureus by microdilution test. The results show an inhibitory activity to E. coli (MIC 512 μg/ml) and S. aureus (MIC 256 μg/ml). The synergism of the essential oil and aminoglycosides was verified too, with significant reduction of MICs (7 ×, 1250-5 μg/ml) against E. coli. It is suggested that the essential oil of Lantana camara Linn could be used as a source of plant-derived natural products with resistance-modifying activity. Medknow Publications 2010-04 2010-05-05 /pmc/articles/PMC2900066/ /pubmed/20668570 http://dx.doi.org/10.4103/0973-1296.62890 Text en © Pharmacognosy Magazine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sousa, Erlânio O.
Silva, Natálya F.
Rodrigues, Fabiola F. G.
Campos, Adriana R.
Lima, Sidney G.
Costa, José Galberto M.
Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn
title Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn
title_full Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn
title_fullStr Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn
title_full_unstemmed Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn
title_short Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn
title_sort chemical composition and resistance-modifying effect of the essential oil of lantana camara linn
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900066/
https://www.ncbi.nlm.nih.gov/pubmed/20668570
http://dx.doi.org/10.4103/0973-1296.62890
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