The global dynamics of RNA stability orchestrates responses to cellular activation

Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. These changes arise from the opposing fluxes of transcription and mRNA decay, both of which affect the functional dynamics of global gene expression. A study published recently in BMC Genomics f...

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Detalles Bibliográficos
Autor principal: Keene, Jack D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900241/
https://www.ncbi.nlm.nih.gov/pubmed/20619007
http://dx.doi.org/10.1186/1741-7007-8-95
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author Keene, Jack D
author_facet Keene, Jack D
author_sort Keene, Jack D
collection PubMed
description Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. These changes arise from the opposing fluxes of transcription and mRNA decay, both of which affect the functional dynamics of global gene expression. A study published recently in BMC Genomics focuses on the contribution made by mRNA stability in shaping the kinetics of gene responses in mammalian cells. See research article http://www.biomedcentral.com/1471-2164/11/259
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spelling pubmed-29002412010-07-09 The global dynamics of RNA stability orchestrates responses to cellular activation Keene, Jack D BMC Biol Commentary Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. These changes arise from the opposing fluxes of transcription and mRNA decay, both of which affect the functional dynamics of global gene expression. A study published recently in BMC Genomics focuses on the contribution made by mRNA stability in shaping the kinetics of gene responses in mammalian cells. See research article http://www.biomedcentral.com/1471-2164/11/259 BioMed Central 2010-07-08 /pmc/articles/PMC2900241/ /pubmed/20619007 http://dx.doi.org/10.1186/1741-7007-8-95 Text en Copyright ©2010 Keene; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Keene, Jack D
The global dynamics of RNA stability orchestrates responses to cellular activation
title The global dynamics of RNA stability orchestrates responses to cellular activation
title_full The global dynamics of RNA stability orchestrates responses to cellular activation
title_fullStr The global dynamics of RNA stability orchestrates responses to cellular activation
title_full_unstemmed The global dynamics of RNA stability orchestrates responses to cellular activation
title_short The global dynamics of RNA stability orchestrates responses to cellular activation
title_sort global dynamics of rna stability orchestrates responses to cellular activation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900241/
https://www.ncbi.nlm.nih.gov/pubmed/20619007
http://dx.doi.org/10.1186/1741-7007-8-95
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