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Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin
BACKGROUND: Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also increases the rate of tr...
Autores principales: | Markou, Thomais, Marshall, Andrew K, Cullingford, Timothy E, Tham, El L, Sugden, Peter H, Clerk, Angela |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900265/ https://www.ncbi.nlm.nih.gov/pubmed/20509958 http://dx.doi.org/10.1186/1471-2164-11-343 |
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